Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism.
Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism.
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DOI：
10.1038/nchem.2202
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发表时间：
2015-04
期刊：
影响因子：
21.8
通讯作者：
Sutherland JD
中科院分区：
文献类型：
--
作者：
Patel BH;Percivalle C;Ritson DJ;Duffy CD;Sutherland JD
一个最小的细胞可以被认为是包括信息，区室形成和代谢子系统。然而，想象这样一个整体系统的非生物组装，对假设的生命前化学提出了很高的要求。这些子系统之间的差异和不兼容性导致了一种普遍的假设，即一个或另一个子系统必须先于其他子系统。在这里，我们已经通过实验研究了这一假设的有效性，通过检查组装的各种生物分子的积木从prebiotically合理的中间体和一碳原料分子。我们表明，前体的核糖核苷酸，氨基酸和脂质都可以通过还原同系物的氰化氢和它的一些衍生物，因此，所有的细胞子系统可以同时出现通过共同的化学。关键反应步骤由紫外光驱动，使用硫化氢作为还原剂，并且可以通过Cu（I）-Cu（II）光氧化还原循环来加速。
A minimal cell can be thought of as comprising informational, compartment-forming and metabolic subsystems. Imagining the abiotic assembly of such an overall system, however, places great demands on hypothetical prebiotic chemistry. The perceived differences and incompatibilities between these subsystems have led to the widely held assumption that one or other subsystem must have preceded the others. Here, we have experimentally investigated the validity of this assumption by examining the assembly of various biomolecular building blocks from prebiotically plausible intermediates and one-carbon feedstock molecules. We show that precursors of ribonucleotides, amino acids and lipids can all be derived by reductive homologation of hydrogen cyanide and some of its derivatives and thus that all the cellular subsystems could have arisen simultaneously through common chemistry. The key reaction steps are driven by UV light, use hydrogen sulfide as reductant and can be accelerated by Cu(I)-Cu(II) photoredox cycling.