PLASMA-RENIN AND ANGIOTENSIN IN DEHYDRATED AND REHYDRATED RATS
PLASMA-RENIN AND ANGIOTENSIN IN DEHYDRATED AND REHYDRATED RATS
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DOI：
10.1152/ajpregu.1986.250.5.r898
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发表时间：
1986-05-01
影响因子：
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通讯作者：
MENDELSOHN, FAO
中科院分区：
文献类型：
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作者：
DINICOLANTONIO, R;MENDELSOHN, FAO
研究了肾素-血管紧张素系统在刺激和终止脱水诱导的饮酒中的作用。脱水48h的大鼠与完全脱水的对照组相比，肾素、血管紧张素II、血浆Na+浓度、渗透压和红细胞压积显著升高。复水后2~4h，脱水大鼠血浆Na+浓度、渗透压和红细胞压积均恢复到正常水平，但复水后血浆肾素和血管紧张素水平进一步升高，并在复水后2~4h显著高于脱水水平。在复水后的8小时内，复水大鼠的肾素和血管紧张素II水平维持在超过循环血管紧张素II的致糖尿病阈值的水平，这表明停止饮酒并不依赖于循环血管紧张素II的减少。最后，尽管血浆血管紧张素II水平超过血管紧张素II的致糖尿病阈值，但复水大鼠在复水后1至8小时内的饮水量并没有明显多于完全对照组，这表明存在超越循环血管紧张素II致糖尿病作用的机制。
The role of the renin-angiotensin system in the stimulation and termination of dehydration-induced drinking was examined in the rat. Rats dehydrated for 48 h had significantly elevated renin, angiotensin II, plasma Na+ concentration, osmolality, and hematocrit when compared with replete controls. Although plasma Na+ concentration, osmolality, and hematocrit of dehydrated rats had returned to control replete levels by 2-4 h after the return of water, the plasma renin and angiotensin II levels exhibited a further increase on rehydration and remained significantly above dehydration levels for 2-4 h after the return of water. The levels of renin and angiotensin II in rehydrated rats were maintained at levels in excess of the dipsogenic threshold for circulating angiotensin II during the 8-h period after rehydration, indicating that termination of the drinking is not dependent on a reduction of circulating angiotensin II. Finally, rehydrated rats did not drink significantly more than replete controls in the 1- to 8-h postrehydration period despite plasma angiotensin II levels in excess of that of the dipsogenic threshold for angiotensin II, indicating that mechanisms exist which override the dipsogenic action of circulating angiotensin II.