Concomitant lower serum albumin and vitamin D levels are associated with decreased objective physical performance among Japanese community-dwelling elderly
Concomitant lower serum albumin and vitamin D levels are associated with decreased objective physical performance among Japanese community-dwelling elderly
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DOI：
10.1159/000103257
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发表时间：
2007-01-01
期刊：
影响因子：
3.5
通讯作者：
Iwasa, Hajime
中科院分区：
文献类型：
--
作者：
Kwon, Jinhee;Suzuki, Takao;Iwasa, Hajime
背景：以往的研究表明，血清白蛋白或维生素D与体能有关。我们假设老年人伴随较低的血清白蛋白和维生素D（25-羟基维生素D，25 OHD）水平与降低的体力活动相比，有1个或没有2个危险因素。目的：探讨社区老年人血清白蛋白和25 OHD水平与体力活动（肌力和平衡能力）的关系。方法：在日本东京的一个以社区为基础的人群中进行横断面研究。在这项研究中，1,094名70岁及以上的社区居民接受了采访，人体测量，血液分析和身体性能测试。结合血清白蛋白和25 OHD水平将受试者分为4型：单纯低白蛋白型、单纯低维生素D型、低白蛋白低维生素D型、高白蛋白高维生素D型。结果如下：伴有低白蛋白和低25 OHD水平的男性，即使在调整了年龄和体重指数（BMI）后，膝关节伸展力量、通常时间Up & Go和最大时间Up & Go也显著降低。在女性中，伴随的低白蛋白和低维生素D与显著降低的握力和功能范围相关，即使在调整了年龄和BMI之后。与高白蛋白和高维生素D水平相比，低白蛋白和低维生素D水平的受试者显示出肌肉力量和平衡能力显著下降，即使在调整了年龄、当前饮酒或吸烟状态、体力活动、慢性病史、基本日常生活活动、工具性日常生活活动、BMI和骨矿物质密度后。结论：伴随的血清白蛋白降低和维生素D水平降低与男性和女性的肌肉力量和平衡能力下降有关。这些结果表明，血清白蛋白和25 OHD一起可能是一个重要的战略目标，旨在实现健康的生活，防止社区居住的老年人失去独立性。版权所有（c）2007 S. Karger AG，巴塞尔。
Background: Previous studies have shown that serum albumin or vitamin D is associated with physical performance. We hypothesized that older adults with concomitant lower serum albumin and vitamin D (25-hydroxyvitamin D, 25OHD) levels are associated with decreased physical performance compared to those with 1 or none of the 2 risk factors. Objective: To investigate the association of combined serum albumin and 25OHD levels with physical performance (muscle strength and balance capability) in community-dwelling elderly. Methods: A cross-sectional study in a community-based population in the province of Tokyo, Japan, was performed. For the study, 1,094 community-dwelling people aged 70 and older underwent an interview, anthropometric measurements, blood analysis and physical performance testing. The subjects were classified into 4 types by combining serum albumin and 25OHD levels: lower albumin only, lower vitamin D only, lower albumin and lower vitamin D, higher albumin and higher vitamin D. Results: Men with concomitant lower albumin and lower 25OHD levels had significantly decreased knee extension power, usual timed Up & Go and maximal timed Up & Go, even after adjusting for age and body mass index (BMI). In women, concomitant lower albumin and lower vitamin D was associated with significantly decreased handgrip strength and functional reach, even after adjusting for age and BMI. Subjects with combined lower albumin and lower vitamin D levels showed a significant decline in muscle strength and balance capability compared to higher albumin and higher vitamin D, even after adjusting for age, current drinking or smoking status, physical activity, history of chronic disease, basic activities of daily living, instrumental activities of daily living, BMI and bone mineral density. Conclusion: Concomitant lower serum albumin and lower vitamin D levels are associated with decreased muscle strength and balance capability in both men and women. These results suggest that serum albumin and 25OHD together may be an important target for strategies aiming to achieve a healthy life and prevent loss of independence in community-dwelling elderly. Copyright (c) 2007 S. Karger AG, Basel.