Reproductive responses to rotenone during decidualized pseudogestation and gestation in rats.
Reproductive responses to rotenone during decidualized pseudogestation and gestation in rats.
复制标题
大鼠蜕膜假妊娠和妊娠期间对鱼藤酮的生殖反应。
DOI：
10.1007/bf01608522
复制
发表时间：
1982
影响因子：
2.7
通讯作者：
Sing,LT
中科院分区：
文献类型：
--
作者：
Spencer,F;Sing,LT
结果稳定i显示，鱼藤酮对脱个体假妊娠大鼠体和子宫湿重有显著影响（p< 0.05）。这些动物，特别是暴露于750 ppm和1000ppm的动物，表现出明显的毒性迹象，即嗜睡和共济失调。肌肉失去协调性)，皮毛粗糙、不整洁。随着体重的变化，饮食摄入量也显著减少。生化参数如子宫蛋白和糖原浓度（图1、2）呈剂量依赖性降低。对这些DCR动物的死后检查显示，暴露于750 ppm和1000 ppm鱼烯酮的大鼠，子宫附近的脂肪组织大大减少。在怀孕研究中，母体生物用高达800 ppm的鱼藤酮处理后，从妊娠第6天到第15天体重下降（表2）。在600和800ppm的剂量下，水坝表现出嗜睡和共济失调的外部毒性迹象。生物化学方面，在剂量高达600ppm时，卵巢蛋白、胎盘蛋白和糖原含量显著降低（p< 0.05）（表3）。这些生化特征的减少不受剂量的影响。
RESULTSTable i shows the significant reductions (p< 0.05) in body and uterine wet weights of decidualized pseudopregnant (DCR) rats fed i0 to i000 ppm of rotenone. Visible signs of toxicity exhibited by these animals, especially those exposed to 750 and I000 ppm, were lethargy and ataxia (. loss of muscular coordination), and a rough, unkempt fur. Significant decreases in dietary consumption accompanied these weight changes. Biochemical parameters like uterine protein and glycogen concentrations (Fig. i, 2) were dimini~ ed in dosage-dependent manners. Post-mortem examination of these DCR animals revealed that the fatty tissues adjacent to uteri were greatly reduced in rats exposed to 750 and I000 ppm of rotenone.In pregnant studies, losses in body weight from Days 6 to 15 of gestation, were demonstrated by maternal organisms treated with up to 800 ppm rotenone (Table 2). At doses of 600 and 800 ppm, dams displayed the external toxic signs of lethargy and ataxia. Biochemically, there were significant decreases (p< 0.05) in ovarian protein, and in placental protein and glycogen contents at doses up to 600 ppm (Table 3). The reductions in these biochemical profiles were unaffected by dosages.