Mast cells can enhance resistance to snake and honeybee venoms
Mast cells can enhance resistance to snake and honeybee venoms
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DOI：
10.1126/science.1128877
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发表时间：
2006-07-28
期刊：
影响因子：
56.9
通讯作者：
Galli, Stephen J.
中科院分区：
文献类型：
--
作者：
Metz, Martin;Piliponsky, Adrian M.;Galli, Stephen J.
蛇或蜜蜂毒液蛰入可导致大量的发病率和死亡率，并且已经提出蛇或昆虫毒液激活肥大细胞可促成这些效应。相反，我们发现，肥大细胞可以显着减少蛇毒诱导的病理小鼠，至少部分通过释放羧肽酶A和其他可能的蛋白酶，可以降解毒液成分。肥大细胞还显著降低蜂毒诱导的发病率和死亡率。这些发现确定了一个新的生物学功能，肥大细胞在增强抵抗疾病和死亡诱导的动物毒液。
Snake or honeybee envenomation can cause substantial morbidity and mortality, and it has been proposed that the activation of mast cells by snake or insect venoms can contribute to these effects. We show, in contrast, that mast cells can significantly reduce snake-venom - induced pathology in mice, at least in part by releasing carboxypeptidase A and possibly other proteases, which can degrade venom components. Mast cells also significantly reduced the morbidity and mortality induced by honeybee venom. These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms.