Gastroenteritis associated with enteric type adenovirus in hospitalized infants.
Gastroenteritis associated with enteric type adenovirus in hospitalized infants.
复制标题
住院婴儿中与肠型腺病毒相关的胃肠炎。
DOI：
10.1016/s0022-3476(82)80173-x
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Strauss,SE
中科院分区：
文献类型：
--
作者：
Yolken,RH;Lawrence,F;Leister,F;Takiff,HE;Strauss,SE
肠道型腺病毒最近被鉴定为婴儿胃肠炎的病原体。我们利用酶免疫分析和组织培养技术，前瞻性地评估ET Ad在住院婴儿腹泻中的作用。我们发现，在秋末冬初为期12周的研究期间，27例腹泻病例中有14例与ET Ad有关; 72例无腹泻儿童中仅1例粪便中发现ET Ad（P<0.001）。虽然在27名腹泻儿童中有2名的粪便中发现了ET Ad以外的腺病毒，但在72名未腹泻儿童中有5名的粪便中也发现了这种病毒，因此在统计学上与急性胃肠炎无关。感染ET Ad的儿童平均腹泻8.0天，而与ET Ad无关的胃肠炎儿童平均腹泻4.2天。14名患有ET Ad胃肠炎的儿童中有13名有呼吸道症状，如咳嗽、流涕或喘息，6名有肺炎的X线证据，3名儿童有双侧结膜炎。本研究证明ET Ad可能是住院婴幼儿急性胃肠道疾病的重要原因，ET Ad引起的胃肠道感染可能与呼吸道疾病的高发病率相关。
Enteric types of adenovirus have recently been identified as a causative agent of infantile gastroenteritis. We utilized enzyme immunoassay and tissue culture techniques to evaluate prospectively the role of ET Ad in diarrhea occurring in hospitalized infants. We found that ET Ad was associated with 14 of 27 cases of diarrhea occurring during a 12-week study period in the late autumn and early winter months; ET Ad was found in the stool of only one of 72 children without diarrhea (P<0.001). Although adenoviruses other than ET Ad were found in the stools of two of the 27 children with diarrhea, such viruses were also found in the stools of five of 72 children without diarrhea and thus could not be statistically correlated with acute gastroenteritis. Children infected with ET Ad had diarrhea for a mean of 8.0 days, compared to a mean duration of 4.2 days for the children with gastroenteritis not associated with ET Ad. Thirteen of the 14 children with ET Ad gastroenteritis had respiratory symptoms such as cough, rhinorrhea, or wheezing, six had roentgenographic evidence of pneumonia, and three children had bilateral conjunctivitis. This study documents that ET Ad can be an important cause of acute gastrointestinal disease in hospitalized infants and young children and that gastrointestinal infections with ET Ad can be associated with a high rate of respiratory disease.