Neurobiology of Tourette's syndrome: concepts of neuroanatomic localization and neurochemical abnormalities
Neurobiology of Tourette's syndrome: concepts of neuroanatomic localization and neurochemical abnormalities
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DOI：
10.1016/s0387-7604(03)90012-x
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发表时间：
2003-12-01
影响因子：
1.7
通讯作者：
Minzer, K
中科院分区：
文献类型：
--
作者：
Singer, HS;Minzer, K
Despite a preponderance of evidence suggesting an organic rather than psychogenic origin for Tourette syndrome, the precise neurobiological abnormality remains speculative. Neuroanatomically, there is expanding confirmation that cortico-striato-thalamo-cortical pathways represent the site of origin for tics and accompanying neuropsychiatric problems. Pathophysiological hypothesis are generally defined based on involvement of (1) a specific anatomical site (striato-thalamic circuits, striatal compartments), (2) physiologic abnormality (excess thalamic excitation, impaired intracortical inhibition), or (3) involvement of a specific neurotransmitter or synaptic component. This review provides information essential for understanding current and future proposals pertaining to the neurobiology of this intriguing disorder. (C) 2003 Elsevier Science B.V. All rights reserved.
