Trimethylamine N-Oxide is Associated with Heart Failure Risk in Patients with Preserved Ejection Fraction
Trimethylamine N-Oxide is Associated with Heart Failure Risk in Patients with Preserved Ejection Fraction
复制标题
三甲胺 N-氧化物与射血分数保留的患者的心力衰竭风险相关
DOI：
10.1093/labmed/lmaa075
复制
发表时间：
2021-07-01
影响因子：
1.3
通讯作者：
Hai, Xin
中科院分区：
文献类型：
--
作者：
Dong, Zengxiang;Zheng, Sijia;Hai, Xin
Background: Trimethylamine N-oxide (TMAO) has been considered to be an independent risk factor of heart failure (HF).Objectives: To further determine the plasma levels of TMAO in patients who have HF with preserved ejection fraction (HFpEF), and to analyze the relationship between TMAO and HFpEF risk. Methods A total of 57 control participants and 61 patients with HFpEF were recruited. We measured and analyzed plasma levels of TMAO and performed biochemical examination of all patients.Results: The mean (SD) plasma levels of TMAO in patients with HFpEF (6.84 [1.12] mu mol/L) were significantly higher than in controls (1.63 [0.08] mu mol/L; P
