Mild hyperbaric oxygen and oxygenation under normobaric conditions: response to Dr. Andel's letter submitted to the editor.
Mild hyperbaric oxygen and oxygenation under normobaric conditions: response to Dr. Andel's letter submitted to the editor.
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轻度高压氧和常压条件下的氧合：对安德尔博士提交给编辑的信的回应。
DOI：
10.1007/s12576-019-00700-w
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Ishihara A.
中科院分区：
文献类型：
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作者：
Matsumoto T;Tanaka M;Ikeji T;Maeshige N;Sakai Y;Akisue T;Kondo H;Ishihara A;Fujino H;Ishihara A.;Ishihara A.
先前的一项研究[1]调查了在常压条件下（1013 hPa）暴露于不同氧浓度（14.4-82.2%）24小时的大鼠的氧化应激和抗氧化水平。该研究中获得的结果[1]不适合应用，并与暴露于轻度高压氧（1226-1317 hPa， 35-40%氧气，1 - 6小时[2]）后观察到的结果进行比较，如Andel博士所建议的。因此，我撤回最近一篇综述文章[2]中描述的内容，即常压条件下氧气浓度超过40%的治疗可能会导致副作用，例如氧化应激水平过高，因为之前没有研究调查常压条件下高浓度氧气对氧化应激水平的时间依赖性副作用。在1317 hPa、含氧量40%的轻度高压氧条件下，血浆溶解氧含量为1.02 mL/dL，其中蒸汽压、肺泡二氧化碳浓度、呼吸交换比分别设定为47 mmHg、40 mmHg、0.8（直接测量血浆溶解氧含量比较困难）。因此，溶解氧的含量由数学公式估算)。在1317 hPa的温和高压氧舱中，可以呼吸40%的氧气，这是由气泵、计算机和氧气浓缩器等控制单元自动调节的，因为舱内空间充足，而且舱内的氧气浓度不受呼气时产生的二氧化碳的影响。在常压条件下（血浆1.02 mL/dL），要获得相似的溶解氧含量，呼吸时需要52.6%的氧气。然而,更多的
A previous study [1] investigated oxidative stress and antioxidant levels in rats exposed to different oxygen concentrations (ranging 14.4–82.2%) under normobaric conditions (1013 hPa) for 24 h. The results obtained in that study [1] were not appropriate to apply and compare with those observed after exposure to mild hyperbaric oxygen, at 1226–1317 hPa with 35–40% oxygen for 1–6 h [2], as suggested by Dr. Andel. Therefore, I withdraw the content, which was described in a recent review article [2], that a treatment with more than 40% oxygen under normobaric conditions can possibly cause side effects, eg, excessive levels of oxidative stress, because there is no previous study that investigated the time-dependent side effects of high oxygen concentration under normobaric conditions on oxidative stress levels.When remaining in mild hyperbaric oxygen at 1317 hPa with 40% oxygen, the content of dissolved oxygen is 1.02 mL/dL blood plasma, where the vapor pressure, concentration of carbon dioxide in the alveolus, and respiratory exchange ratio are set to 47 mmHg, 40 mmHg, and 0.8, respectively (it is difficult to measure directly the content of dissolved oxygen in the blood plasma. Therefore, the content of dissolved oxygen was estimated by a mathematical formula). Breathing with 40% oxygen, which is automatically regulated by a control unit including an air-pump, a computer, and an oxygen concentrator, is possible when staying in a mild hyperbaric oxygen chamber at 1317 hPa, because the chamber has ample space and oxygen concentration in the chamber is not affected by carbon dioxide induced by expiration. To obtain the similar content of dissolved oxygen under normobaric conditions (1.02 mL/dL blood plasma), breathing with 52.6% oxygen is necessary. However, more