An outlook on future design of hybrid PET/MRI systems
An outlook on future design of hybrid PET/MRI systems
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DOI：
10.1118/1.3633909
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发表时间：
2011-10-01
期刊：
影响因子：
3.8
通讯作者：
Del Guerra, Alberto
中科院分区：
文献类型：
--
作者：
Zaidi, Habib;Del Guerra, Alberto
早期诊断和治疗越来越多地在细胞、分子甚至基因水平上进行。随着诊断技术从系统水平向分子水平的过渡，多模式分子成像的作用变得越来越重要。正电子发射断层扫描(PET)和磁共振成像(MRI)是体内分子成像的强大技术。PET不能提供解剖信息是独立PET系统的一个主要限制。结合PET和CT被证明是临床相关的，并通过提供代谢异常定位所需的解剖学信息成功地减少了这一限制。然而，这项技术仍然缺乏MRI提供的出色软组织对比度。独立的磁共振成像系统揭示结构和功能，但不能在分子水平上提供对生理和/或病理的洞察。PET和MRI的结合，实现了真正的同步采集，弥合了分子诊断和系统诊断之间的差距。MRI和PET提供了丰富的互补功能和灵敏度；融合到一个提供同时采集的组合系统中将充分利用各自的优势，提供一种远远优于其各部分总和的混合技术。一个组合的PET/MRI系统同时提供了MRI的解剖和结构描述以及PET的定量能力。此外，这种系统将允许利用磁共振波谱(MRS)的力量来测量区域生化含量，并评估特定组织区域的代谢状态或肿瘤和其他疾病的存在。本文简要总结了专用混合PET/MRI仪器的最新发展和最新进展。并对该技术的发展前景和临床应用前景进行了讨论。(C)2011年美国医学物理学家协会。[DOI：10.1118/1.3633909]
Early diagnosis and therapy increasingly operate at the cellular, molecular, or even at the genetic level. As diagnostic techniques transition from the systems to the molecular level, the role of multimodality molecular imaging becomes increasingly important. Positron emission tomography (PET) and magnetic resonance imaging (MRI) are powerful techniques for in vivo molecular imaging. The inability of PET to provide anatomical information is a major limitation of standalone PET systems. Combining PET and CT proved to be clinically relevant and successfully reduced this limitation by providing the anatomical information required for localization of metabolic abnormalities. However, this technology still lacks the excellent soft-tissue contrast provided by MRI. Standalone MRI systems reveal structure and function but cannot provide insight into the physiology and/or the pathology at the molecular level. The combination of PET and MRI, enabling truly simultaneous acquisition, bridges the gap between molecular and systems diagnosis. MRI and PET offer richly complementary functionality and sensitivity; fusion into a combined system offering simultaneous acquisition will capitalize the strengths of each, providing a hybrid technology that is greatly superior to the sum of its parts. A combined PET/MRI system provides both the anatomical and structural description of MRI simultaneously with the quantitative capabilities of PET. In addition, such a system would allow exploiting the power of MR spectroscopy (MRS) to measure the regional biochemical content and to assess the metabolic status or the presence of neoplasia and other diseases in specific tissue areas. This paper briefly summarizes state-of-the-art developments and latest advances in dedicated hybrid PET/MRI instrumentation. Future prospects and potential clinical applications of this technology will also be discussed. (C) 2011 American Association of Physicists in Medicine. [DOI: 10.1118/1.3633909]