A Lytic Viral Long Noncoding RNA Modulates the Function of a Latent Protein
A Lytic Viral Long Noncoding RNA Modulates the Function of a Latent Protein
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DOI：
10.1128/jvi.03251-13
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发表时间：
2014-02-01
影响因子：
5.4
通讯作者：
Izumiya, Yoshihiro
中科院分区：
文献类型：
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作者：
Campbell, Mel;Kim, Kevin Y.;Izumiya, Yoshihiro
潜伏的卡波西肉瘤相关疱疹病毒(KSHV)上体包被病毒潜伏相关核抗原(LANA)。相反，LANA在重新激活过程中迅速与外周小体解离。裂解KSHV表达多腺苷核糖核酸(PAN RNA)，一种长的非编码RNA(LncRNA)。我们报道，PAN RNA通过与LANA相互作用促进LANA-Episome解离，从而促进LANA在重新激活过程中从KSHV表观体内分离出来。这些发现表明，KSHV可能进化出一种RNA适配子来调节潜在的蛋白质功能。
Latent Kaposi's sarcoma-associated herpesvirus (KSHV) episomes are coated with viral latency-associated nuclear antigen (LANA). In contrast, LANA rapidly disassociates from episomes during reactivation. Lytic KSHV expresses polyadenylated nuclear RNA (PAN RNA), a long noncoding RNA (lncRNA). We report that PAN RNA promotes LANA-episome disassociation through an interaction with LANA which facilitates LANA sequestration away from KSHV episomes during reactivation. These findings suggest that KSHV may have evolved an RNA aptamer to regulate latent protein function.