A direct role for Hsp90 in pre-RISC formation in Drosophila
A direct role for Hsp90 in pre-RISC formation in Drosophila
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DOI：
10.1038/nsmb.1875
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发表时间：
2010-08-01
影响因子：
16.8
通讯作者：
Siomi, Mikiko C.
中科院分区：
文献类型：
--
作者：
Miyoshi, Tomohiro;Takeuchi, Akiko;Siomi, Mikiko C.
Heat-shock proteins (Hsps) are molecular chaperones that control protein folding and function. Argonaute 2 (Ago2), the effector in RNA interference (RNAi), is associated with Hsp90; however, its function in RNAi remains elusive. Here we show that Hsp90 is required for Ago2 to receive the small interfering RNA (siRNA) duplex from the RNA-induced silencing complex-loading complex in RNAi, suggesting a model where Hsp90 modifies Ago2 conformation to accommodate the siRNA duplex.
