Maternal medication use and neuroblastoma in offspring
Maternal medication use and neuroblastoma in offspring
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DOI：
10.1093/aje/kwh108
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发表时间：
2004-04-15
影响因子：
5
通讯作者：
Pollock, BH
中科院分区：
文献类型：
--
作者：
Cook, MN;Olshan, AF;Pollock, BH
在一项病例对照研究中，评估了母亲在怀孕和哺乳期使用特定药物与其后代神经母细胞瘤之间的联系。美国和加拿大新诊断的神经母细胞瘤病例(n=504)是在1992年至1994年期间在附属于儿科肿瘤组或儿童癌症组临床试验计划的139家医院发现的。采用随机数字拨号的方法，从每个病例的社区中抽取1名年龄匹配的对照。接触信息是在一次有组织的电话采访中从母亲那里回溯确定的。使用条件Logistic回归估计优势比，并对母亲的社会人口因素进行调整。结果不支持神经母细胞瘤与母亲接触利尿剂、抗感染药物、雌激素、孕激素、镇静剂、抗惊厥药物或可能形成N-亚硝基衍生物的药物之间的联系。病例母亲在怀孕或哺乳期间报告使用含有阿片类激动剂的药物的可能性比对照母亲更高(优势比=2.4，95%可信区间：1.3，4.3)。具体地说，病例的母亲报告在怀孕或哺乳期间使用含有可待因的药物的人数比对照组的母亲多(优势比=3.4，95%可信区间：1.4，8.4)。这一初步发现可能是由于偏见、混淆或偶然，还需要更多的研究来证实。
The association between a mother's use of specific medications during pregnancy and lactation and neuroblastoma in her offspring was evaluated in a case-control study. Newly diagnosed cases of neuroblastoma (n = 504) in the United States and Canada were identified between 1992 and 1994 at 139 hospitals affiliated with the Pediatric Oncology Group or the Children's Cancer Group clinical trial programs. One age-matched control was sampled from the community of each case by means of random digit dialing. Exposure information was ascertained retrospectively from mothers in a structured telephone interview. Odds ratios were estimated using conditional logistic regression, with adjustment for maternal sociodemographic factors. The results did not support an association between neuroblastoma and maternal exposure to diuretic agents, antiinfective agents, estrogens, progestins, sedatives, anticonvulsant drugs, or drugs that may form N-nitroso derivatives. Mothers of cases were more likely to report using medications containing opioid agonists while they were pregnant or nursing than were mothers of controls (odds ratio = 2.4, 95% confidence interval: 1.3, 4.3). Specifically, more mothers of cases reported using medications containing codeine while pregnant or nursing than did mothers of controls (odds ratio = 3.4, 95% confidence interval: 1.4, 8.4). This preliminary finding may be due to bias, confounding, or chance, and additional studies are needed for confirmation.