β2-microglobulin serum level is not a marker of disease activity in multiple sclerosis
β2-microglobulin serum level is not a marker of disease activity in multiple sclerosis
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DOI：
10.1111/j.1468-1331.2004.00808.x
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发表时间：
2004-07-01
影响因子：
5.1
通讯作者：
Millefiorini, E
中科院分区：
文献类型：
--
作者：
Bagnato, F;Zivadinov, R;Millefiorini, E
β 2-微球蛋白（β 2-MG）是多发性硬化症（MS）中干扰素-β活性的药效学标志物。它在疾病自然过程中的作用尚不完全清楚。我们分析了短期内免费治疗MS患者中β 2-MG的自发波动，以量化β 2-MG作为疾病活动/进展的标志物。在3个月的时间内，每月对30名MS患者进行临床评估和成像。同时收集血清，通过酶联免疫吸附试验评价β 2-MG。抽取20名健康人（HI）的血清作为对照。适当时使用Mann-Whitney检验，并通过随机效应模型评估放射学和生物学指标的时间效应。8例（26.7%）患者出现临床复发，但3例（10%）患者需要类固醇治疗。观察到对比增强病变负荷降低（P = 0.02）和脑实质分数降低的趋势（P = 0.07）。患者和HI患者的β 2-MG基线水平相似。患者的β 2-MG值在3个月的时间段内增加（P = 0.05），但在任何时间点均未超过HI中检测到的值。这些结果未能证明β 2-MG作为MS疾病替代标志物的有效性。
Beta2-microglobulin (beta2-MG) is a pharmacodynamic marker of interferon-beta activity in multiple sclerosis (MS). Its role in the natural course of the disease is not fully known. We analyzed the spontaneous fluctuation of beta2-MG in free-treatment MS patients during a short-time course to quantify beta2-MG as a marker of disease activity/progression. Thirty MS patients were clinically assessed and imaged monthly over a 3-month period. Sera were collected concomitantly for the evaluation of beta2-MG, by means of an enzyme-linked immunosorbent assay. Sera from 20 healthy individuals (HI) were drawn and used as controls. The Mann-Whitney test was used when appropriate and time effect on radiological and biological measures was assessed by means of the random effect models. Eight (26.7%) patients experienced a clinical relapse but three (10%) required steroid treatment. A reduction in the contrast-enhancing lesion load (P = 0.02) and a trend (P = 0.07) toward a decrease in brain parenchyma fraction were observed. Baseline levels of beta2-MG were similar in patients and HI. Patients'beta2-MG values increased over the 3-month time period (P = 0.05) but did not exceed those detected in HI at any time point. These results failed to demonstrate the validity of beta2-MG as a surrogate marker of disease in MS.