Mechanism of polyuria and natriuresis in atrioventricular nodal tachycardia.
Mechanism of polyuria and natriuresis in atrioventricular nodal tachycardia.
复制标题
房室结性心动过速多尿和排钠的机制。
作者：
R. CANEPA;M. Williams;J. Marshall;T. Mitsuoka;S. Lightman;R. Sutton
对一例多尿伴心动过速的妇女进行了调查。电生理分析表明，该心动过速为房室结折返性心动过速。然后使用程序刺激来刺激和维持心动过速40分钟。观察到多尿症，游离水清除率明显增加。这与血浆和尿液中精氨酸加压素浓度的降低有关。此外，还出现了明显的利钠作用。这些结果支持这一假说，即人类持续心动过速时出现的自由水清除增加的多尿和利钠是由于血管加压素的分泌受到抑制和利钠因子的释放。
A woman with tachycardia associated with polyuria was investigated. Electrophysiological analysis showed that the tachycardia was an atrioventricular nodal re-entrant tachycardia. Programmed stimulation was then used to provoke and sustain the tachycardia for 40 minutes. Polyuria, with an appreciable increase in free water clearance, was observed. This was associated with reduction in plasma and urinary arginine vasopressin concentrations. Appreciable natriuresis also developed. These results support the hypothesis that the polyuria with increased free water clearance and the natriuresis occurring during sustained tachycardia in man are due to inhibition of secretion of vasopressin and the release of natriuretic factor.