Safety of lamotrigine in paediatrics: a systematic review.
Safety of lamotrigine in paediatrics: a systematic review.
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DOI：
10.1136/bmjopen-2015-007711
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发表时间：
2015-06-12
期刊：
影响因子：
2.9
通讯作者：
Sammons HM
中科院分区：
文献类型：
--
作者：
Egunsola O;Choonara I;Sammons HM
确定儿童与拉莫三嗪相关的药物不良反应，并与其他抗癫痫药物的安全性进行比较。检索了EMBASE（1974 - 2015年4月）、MEDLINE（1946 - 2015年4月）、PubMed和Cochrane随机对照试验库等数据库，以检索拉莫三嗪的安全性研究。所有涉及年龄≤18岁且接受过至少单剂量拉莫三嗪并以安全性作为结局指标的儿科患者的研究均被纳入。主要结局指标为拉莫三嗪的安全性。拉莫三嗪的药物相互作用是次要结果。共发现78篇文章，涉及3783名儿科患者。报告了2222例不良事件（ae）。皮疹是最常见的AE，发生率为7.3%。史蒂文斯-约翰逊综合征很少被报道，其风险为0.09 / 100。72名儿童（占所有治疗患者的1.9%）因药物不良反应（ADR）停药。58%的治疗中断是由于不同形式的皮疹，21%是由于癫痫发作增加。接受拉莫三嗪单药治疗的儿童不良事件发生率较低。单药组儿童的头痛（p=0.02）、嗜睡（<0.001）、恶心（p=0.01）、呕吐（p<0.001）、头晕（p<0.001）和腹痛（p=0.01）明显降低。皮疹是拉莫三嗪最常见的不良反应和最常见的停药原因。接受综合治疗的儿童发生不良反应的风险高于接受单一治疗的儿童。CRD42013006910。
To identify adverse drug reactions associated with lamotrigine in children and compare the safety profile with other antiepileptic drugs. Databases EMBASE (1974–April 2015), MEDLINE (1946–April 2015), PubMed and the Cochrane library for randomised controlled trials were searched for studies on safety of lamotrigine. All studies involving paediatric patients aged ≤18 years who have received at least a single dose of lamotrigine with safety as an outcome measure were included. The primary outcome measure was safety of lamotrigine. Drug interaction of lamotrigine was the secondary outcome. A total of 78 articles involving 3783 paediatric patients were identified. There were 2222 adverse events (AEs) reported. Rash was the most commonly reported AE, occurring in 7.3% of the patients. Stevens-Johnson syndrome was rarely reported, with a risk of 0.09 per 100 patients. Discontinuation due to an adverse drug reaction (ADR) was recorded in 72 children (1.9% of all treated patients). Fifty-eight per cent of treatment discontinuation was attributed to different forms of rash and 21% due to increased seizures. Children on lamotrigine monotherapy had lower incidences of AEs. Headache (p=0.02), somnolence (<0.001), nausea (p=0.01), vomiting (p<0.001), dizziness (p<0.001) and abdominal pain (p=0.01) were significantly lower among children on monotherapy. Rash was the most common ADR of lamotrigine and the most common reason for treatment discontinuation. Children receiving polytherapy have a higher risk of AEs than monotherapy users. CRD42013006910.
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影响因子：
2.2
作者：
Holmes, Gregory L.;Frank, L. Matthew;Sheth, Raj D.;Philbrook, Bryan;Wooten, John D.;Vuong, Alain;Kerls, Susan;Hammer, Anne E.;Messenheimer, John
通讯作者：
Messenheimer, John
影响因子：
3.7
作者：
Harr T;French LE
通讯作者：
French LE
DOI：
10.1056/nejmoa0902014
发表时间：
2010-03-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Glauser TA;Cnaan A;Shinnar S;Hirtz DG;Dlugos D;Masur D;Clark PO;Capparelli EV;Adamson PC;Childhood Absence Epilepsy Study Group
通讯作者：
Childhood Absence Epilepsy Study Group
影响因子：
5.6
作者：
Coppola, G;Auricchio, G;Pascotto, A
通讯作者：
Pascotto, A
影响因子：
5.6
作者：
Guerrini, R;Dravet, C;Dulac, O
通讯作者：
Dulac, O