Investigating relations between environmental toxins in Northern Irish soils and streams and Chronic Kidney Disease prevalence
Investigating relations between environmental toxins in Northern Irish soils and streams and Chronic Kidney Disease prevalence
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DOI：
10.1016/j.apgeochem.2016.10.016
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发表时间：
2016-12-01
影响因子：
3.4
通讯作者：
Palmer, Sherry
中科院分区：
文献类型：
--
作者：
Jackson, Chloe E.;McKinley, Jennifer M.;Palmer, Sherry
慢性肾脏病（CKD）的病因不明引起了最近的关注，这是由于全球患病率不断增加以及最近对肾毒素职业和环境暴露的审查。本研究的主要重点是检查环境暴露于已知的肾毒素（包括砷、镉和铅）之间的潜在关系，以及北方爱尔兰的CKD肾损害患者中与肾脏进行性功能障碍相关的潜在健康风险。除了这些已知的肾毒素外，已发现与几种必需元素的共丰度起到保护机制的作用，而其他元素由于体内类似的吸收机制而增加肾毒性元素的吸收。保护身体免受毒性的关键元素包括硒和锌，而那些被认为可以增强砷，镉和铅的吸收的元素包括铁和钙。土壤和流地球化学数据的组成性质进行了探讨，以帮助元素之间的相互作用的分析。探索了两种方法，一种是数据驱动的，另一种是知识驱动的，来研究共同丰富元素之间的关联。这些元素的生物可及性，这是体内吸收的相关毒素的一部分，也进行了调查，以确定整个北方爱尔兰地区的环境危害和潜在的健康风险增加。该研究使用了来自英国肾脏登记处（UKRR）未知病因子集的数据集、来自Tellus调查（GSNI）的土壤和河流地球化学数据集以及生物可及性子集的组合。研究结果表明，在流沃茨中的砷含量升高和肾功能受损之间的关系。必需元素和潜在的有毒元素之间的相互作用可以解释整个北方爱尔兰的病因不明的CKD的区域变化。(C)2016爱思唯尔有限公司版权所有
The unknown aetiology of Chronic Kidney Disease (CKD) has attracted recent attention as a result of the increasing global prevalence and recent reviews of occupational and environmental exposure to nephrotoxins. The main focus of this research is to examine the potential relationship between environmental exposure to known nephrotoxins including arsenic, cadmium and lead and, the potential health risk associated with the progressive dysfunction of the kidneys in renal impaired patients with CKD across Northern Ireland. In addition to these known nephrotoxins, co-abundance with several essential elements has been found to play a role as protecting mechanisms while others increase the uptake of nephrotoxic elements as a result of similar absorption mechanisms within the body. Key elements protecting the body from toxicity include selenium and zinc, whereas those which have been attributed to enhance the uptake of arsenic, cadmium and lead include iron and calcium. The compositional nature of the soil and stream geochemical data is explored to aid in the analysis of interactions between elements. Two approaches, one data-driven and the other knowledge-driven, are explored to investigate the associations between co-abundant elements. The bioaccessibility of these elements, which is the portion of the relevant toxin absorbed within the body, is also investigated to identify areas across Northern Ireland with an increased environmental hazard and potential health risk. The study uses a combination of datasets from the United Kingdom Renal Registry (UKRR) unknown aetiology subset, the soil and stream geochemical dataset from the Tellus Survey (GSNI) with the addition of a bioaccessibility subset. Findings suggest a relationship between the presence of elevated arsenic in stream waters and impaired renal function of the kidneys. Interactions between essential elements and potentially toxic elements could explain the regional variation of CKD of uncertain aetiology across Northern Ireland. (C) 2016 Elsevier Ltd. All rights reserved.