Effect of dietary supplementation of astaxanthin by Phaffia rhodozyma on lipid peroxidation, drug metabolism and some immunological variables in male broiler chicks fed on diets with or without oxidised fat
Effect of dietary supplementation of astaxanthin by Phaffia rhodozyma on lipid peroxidation, drug metabolism and some immunological variables in male broiler chicks fed on diets with or without oxidised fat
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DOI：
10.1080/00071660601156453
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发表时间：
2007-02-01
影响因子：
2
通讯作者：
Akiba, Y.
中科院分区：
文献类型：
--
作者：
Takimoto, T.;Takahashi, K.;Akiba, Y.
1.研究了红发夫酵母提供的虾青素(Ax)对公鸡体内脂质过氧化、肝脏药物代谢、抗绵羊红细胞抗体效价和脾细胞对有丝分裂原增殖的影响。1周龄雏鸡随机饲喂含或不含氧化脂肪(0或3.7MEQ的过氧化值(POV)/kg日粮)和/或Ax(0或100 mg/kg日粮)14d。以2-硫代巴比妥酸反应物测定肝、脾、心脏、血浆和肝微粒体中的脂质过氧化程度，饲喂含氧化脂肪的日粮(P<；0.05)，但不影响Ax饲喂。肝微粒体中细胞色素P-450的含量随饲喂Ax.5的增加而增加。氧化脂肪和Ax饲料对抗SRBC效价无影响，而血浆免疫球蛋白(Ig)G浓度随Ax饲料的增加而升高，但不受氧化脂肪饲料的影响。当饲喂不含氧化脂肪的日粮时，Ax促进刀豆蛋白A和商陆有丝分裂原刺激的脾细胞增殖，而在饲喂含有氧化脂肪的日粮中，Ax抑制脾细胞的增殖(P<；0.01，Ax和氧化脂肪交互作用)。结果表明，日粮中添加红发夫酵母Ax对公鸡T细胞增殖和免疫球蛋白生成有一定的影响，但不能有效地防止公鸡体内的脂质过氧化。
1. Effects of dietary supplementation of astaxanthin (Ax) provided from Phaffia rhodozyma on lipid peroxidation, hepatic drug metabolism, antibody titres to sheep red blood cells (SRBC) and splenocyte proliferation to mitogens were determined in male broiler chicks.2. Chicks, one week old, were given diets with or without oxidised fat (0 or 3.7 meq of peroxide value (POV)/kg diet) and/or Ax (0 or 100 mg/kg diet) for 14 d, ad libitum.3. Lipid peroxidation, estimated by 2-thiobarbituric acid reactants values in liver, spleen, heart, plasma and hepatic microsomes, were increased by feeding a diet containing oxidised fat (P < 0.05) but were not affected by Ax feeding.4. Cytochrome P-450 contents in hepatic microsome tended to be increased by feeding Ax.5. Anti-SRBC titre was not affected by oxidised fat or Ax feeding, while plasma immunogloblin (Ig) G concentration was increased by Ax feeding but was not affected by oxidised fat feeding.6. When chicks were fed on the diet without oxidised fat, Ax enhanced splenocyte proliferation stimulated by both concanavalin A and pokeweed mitogen, while in chicks fed on a diet containing oxidised fat, Ax reduced the proliferation (P < 0.01 for Ax and oxidised fat interaction).7. The results indicated that dietary supplementation of Ax from Phaffia rhodozyma had an impact on T cell proliferation and Ig G production as a part of acquired immunity, but was not effective in preventing lipid peroxidation in male broiler chicks.