Heritability of cigarette smoking and alcohol use in Chinese male twins: the Qingdao twin registry
Heritability of cigarette smoking and alcohol use in Chinese male twins: the Qingdao twin registry
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DOI：
10.1093/ije/dyl148
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发表时间：
2006-10-01
影响因子：
7.7
通讯作者：
Lee, Liming
中科院分区：
文献类型：
--
作者：
Lessov-Schlaggar, Christina N.;Pang, Zengchang;Lee, Liming
中国是世界上吸烟人数最多的国家（3.5亿），酒精消费量也在不断上升，但对烟草和酒精使用的病因学知之甚少。在2000年，中国国家双胞胎登记处成立，提供了一个遗传信息资源的健康行为，包括烟草和酒精use.Methods使用标准的双胞胎方法，本研究旨在研究吸烟和饮酒的样本中的成年中国双胞胎（n = 1010个单独的双胞胎）的遗传和环境的影响的相对贡献。超过一半的男性双胞胎是吸烟者（58%），32.5%的人报告饮酒。在男性吸烟者中，46.4%的人每天吸烟20支或更多（重度吸烟者），在饮酒者中，32.8%的人每天饮酒一次或多次。几乎所有的女性双胞胎是不吸烟者（99.2%）和非饮酒者（98.7%），因此，遗传分析仅限于男性data.Results在男性，目前吸烟显着遗传[75.1%，95%的置信区间（CI）56.7-87.5]，没有证据表明共享的环境影响的显着贡献。与共享环境（8.7%，95%CI 0-71.0）相比，基因（66.2%，95%CI 0-88.4）对重度吸烟的影响更大。同样，当前饮酒受遗传效应（59.5%，95%CI 0-87.8）的影响比受共同环境效应（15.3%，95%CI 0-72.1）的影响更大。饮酒量的影响程度相似的遗传（42.4%，95%CI 0-91.8）和共享的环境因素（39.2%，95%CI 0-82.7）。结论这些结果支持的研究结果，从西方起源的双胞胎吸烟和饮酒的病因，并鼓励进一步的工作，在中国双胞胎。
Background China has the world's largest concentration of smokers (350 million) and rising alcohol consumption, yet little is known about tobacco and alcohol use aetiology. In 2000, the Chinese National Twin Registry was established to provide a genetically informative resource for investigation of health behaviour including tobacco and alcohol use.Methods Using standard twin methodology, this study aimed to examine the relative contribution of genetic and environmental influences on cigarette smoking and alcohol drinking in a sample of adult Chinese twins (n = 1010 individual twins). More than half of the male twins were smokers (58%), and 32.5% reported alcohol consumption. Among male smokers, 46.4% smoked 20 or more cigarettes per day (heavy smokers) and among drinkers, 32.8% consumed one or more drinks per day. Nearly all female twins were non-smokers (99.2%) and non-drinkers (98.7%); therefore, genetic analysis was limited to male data.Results In men, current smoking was significantly heritable [75.1%, 95% confidence interval (CI) 56.7-87.5] with no evidence for a significant contribution of shared environmental effects. Heavy smoking was more strongly influenced by genes (66.2%, 95% CI 0-88.4) than shared environment (8.7%, 95% CI 0-71.0). Similarly, current drinking was more strongly influenced by genetic effects (59.5%, 95% CI 0-87.8) than by shared environmental effects (15.3%, 95% CI 0-72.1). Amount of alcohol consumed was influenced to a similar degree by genetic (42.4%, 95% CI 0-91.8) and shared environmental factors (39.2%, 95% CI 0-82.7).Conclusions These results support findings from twins of Western origin on the aetiology of tobacco and alcohol use and encourage further work in Chinese twins.