Quantitative trait loci affecting a courtship signal in Drosophila melanogaster
Quantitative trait loci affecting a courtship signal in Drosophila melanogaster
复制标题
DOI：
10.1038/sj.hdy.6800099
复制
发表时间：
2002-07-01
期刊：
影响因子：
3.8
通讯作者：
Ritchie, MG
中科院分区：
文献类型：
--
作者：
Gleason, JM;Nuzhdin, SV;Ritchie, MG
求偶在物种的性隔离中起着重要作用，但求偶行为背后的遗传学却知之甚少。在这里，我们分析了数量性状基因座（QTL）的主要组成部分的求爱歌重组近交系来自两个实验室品系的果蝇。品系之间的总变异超过了亲本品系之间的变异，并且与该物种的世界性形式的地理品系之间的变异大致相似。以往对果蝇鸣声数量遗传学的研究表明，果蝇鸣声是一种多基因加性遗传，许多基因分布在整个基因组中。我们发现只有三个显着的QTL解释54%的遗传变异的证据。因此，有证据表明，一些大的影响基因的遗传变异线之间的贡献。有趣的是，几乎所有的候选歌曲基因先前描述的D。与我们的QTL不一致。
Courtship plays a major role in the sexual isolation of species, yet the genetics underlying courtship behaviour are poorly understood. Here we analyse quantitative trait loci (QTL) for a major component of courtship song in recombinant inbred lines derived from two laboratory strains of Drosophila melanogaster. The total variance among lines exceeds that between parental strains, and is broadly similar to that seen among geographic strains of the Cosmopolitan form of this species. Previous studies of the quantitative genetics of fly song have implied a Polygenic additive inheritance with numerous genes spread throughout the genome. We find evidence for only three significant QTLs explaining 54% of the genetic variance in total. Thus there is evidence for a few large effect genes contributing to the genetic variance among lines. Interestingly, almost all of the candidate song genes previously described for D. melanogaster do not coincide with our QTLs.