Disrupting Parietal Function Prolongs Dominance Durations in Binocular Rivalry
Disrupting Parietal Function Prolongs Dominance Durations in Binocular Rivalry
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DOI：
10.1016/j.cub.2010.10.046
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发表时间：
2010-12-07
期刊：
影响因子：
9.2
通讯作者：
Bartels, Andreas
中科院分区：
文献类型：
--
作者：
Zaretskaya, Natalia;Thielscher, Axel;Bartels, Andreas
双稳态感知现象的人脑成像研究表明，在两种相互冲突的感知之间的感知切换过程中，额叶和顶叶区域被激活[1-3]。然而，这些研究并没有提供关于因果关系的信息，也就是说，活动是否报告了感知变化的结果或原因。在这里，我们使用功能性磁共振成像分别定位了15名受试者在双目竞争中参与感知开关的四个顶叶区域，随后在双眼竞争中使用2hz重复经颅磁刺激（TMS）干扰他们的神经加工和对照部位。我们发现，经颅磁刺激其中一个部位，即右侧顶叶内沟（IPS），延长了稳定知觉的时间。此外，IPS中依赖血氧水平的信号越偏侧，TMS效应越偏侧。侧化在不同受试者之间差异很大，右半球偏倚。对照回放实验排除了经颅磁刺激对任务表现、反应时间或眨眼的非特异性影响。因此，我们的研究结果表明，正常IPS功能对竞争中的感知连续性具有因果关系、不稳定和个体侧化的影响。这与IPS在知觉选择中的作用是一致的，将其在竞争性知觉中的作用与注意中的作用联系起来[4-6]。
Human brain imaging studies of bistable perceptual phenomena revealed that frontal and parietal areas are activated during perceptual switches between the two conflicting percepts [1-3]. However, these studies do not provide information about causality, i.e., whether activity reports a consequence or a cause of the perceptual change. Here we used functional magnetic resonance imaging to individually localize four parietal regions involved in perceptual switches during binocular rivalry in 15 subjects and subsequently disturbed their neural processing and that of a control site using 2 Hz repetitive transcranial magnetic stimulation (TMS) during binocular rivalry. We found that TMS over one of the sites, the right intraparietal sulcus (IPS), prolonged the periods of stable percepts. Additionally, the more lateralized the blood oxygen level-dependent signal was in IPS, the more lateralized the TMS effects were. Lateralization varied considerably across subjects, with a right-hemispheric bias. Control replay experiments rule out nonspecific effects of TMS on task performance, reaction times, or eye blinks. Our results thus demonstrate a causal, destabilizing, and individually lateralized effect of normal IPS function on perceptual continuity in rivalry. This is in accord with a role of IPS in perceptual selection, relating its role in rivalrous perception to that in attention [4-6].