(68)Ga-PRGD2 PET/CT in the evaluation of Glioma: a prospective study.
(68)Ga-PRGD2 PET/CT in the evaluation of Glioma: a prospective study.
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(68)Ga-PRGD2 PET/CT 评估神经胶质瘤：一项前瞻性研究。
DOI：
10.1021/mp5003224
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发表时间：
2014-11-03
影响因子：
4.9
通讯作者：
Zhu Z
中科院分区：
文献类型：
--
作者：
Li D;Zhao X;Zhang L;Li F;Ji N;Gao Z;Wang J;Kang P;Liu Z;Shi J;Chen X;Zhu Z
整合素αvβ3在新生血管细胞和胶质瘤细胞中均过表达。我们的目的是评估68ga - bnota - prgd2 （68Ga-PRGD2）作为胶质瘤患者无创整合素αvβ3成像的新试剂。在知情同意的情况下，入选12例经增强磁共振成像（MRI）扫描诊断为可疑脑胶质瘤的患者，术前进行68Ga-PRGD2 PET/CT和18F-FDG PET/CT扫描。将术前图像与病理确定的WHO分级进行比较。免疫组化染色检测肿瘤组织中整合素αvβ3、CD34、Ki-67的表达。我们的研究结果表明，68Ga-PRGD2特异性地在富含整合素αvβ3和其他新生血管标志物的脑肿瘤中积累，而不是在脉络膜丛以外的脑实质中积累。因此，68Ga-PRGD2 PET/CT能够比18F-FDG PET/CT更特异性地评估胶质瘤的界限。68Ga-PRGD2的最大标准化摄取值（SUVmax）与胶质瘤分级显著相关，而不是18F-FDG。两种示踪剂的最大瘤脑比（TBRmax）与胶质瘤分级显著相关，而68Ga-PRGD2在区分高级别胶质瘤（HGG）和低级别胶质瘤（LGG）方面似乎比18F-FDG更优越。此外，68Ga-PRGD2 PET/CT显示WHO分级III级和IV级HGG的积累模式不同。据我们所知，这是我们首次在术前不同级别胶质瘤患者中进行的无创整合素成像研究，初步表明了这种新方法对胶质瘤分级和划分的有效性。
Integrin αvβ3 is overexpressed in both neovasculature and glioma cells. We aimed to evaluate 68gallium-BNOTA-PRGD2 (68Ga-PRGD2) as a new reagent for noninvasive integrin αvβ3 imaging in glioma patients. With informed consent, 12 patients with suspicious brain glioma, as diagnosed by enhanced magnetic resonance imaging (MRI) scanning, were enrolled to undergo 68Ga-PRGD2 PET/CT and 18F-FDG PET/CT scans before surgery. The preoperative images were compared and correlated with the pathologically determined WHO grade. Next, the expression of integrin αvβ3, CD34, and Ki-67 were determined by immunohistochemical staining of the resected brain tumor tissue. Our findings demonstrated that 68Ga-PRGD2 specifically accumulated in the brain tumors that were rich of integrin αvβ3 and other neovasculature markers, but not in the brain parenchyma other than the choroid plexus. Therefore, 68Ga-PRGD2 PET/CT was able to evaluate the glioma demarcation more specifically than 18F-FDG PET/CT. The maximum standardized uptake values (SUVmax) of 68Ga-PRGD2, rather than those of 18F-FDG, were significantly correlated with the glioma grading. The maximum tumor-to-brain ratios (TBRmax) of both tracers were significantly correlated with glioma grading, whereas 68Ga-PRGD2 seemed to be more superior to 18F-FDG in differentiating high-grade glioma (HGG) from low-grade glioma (LGG). Moreover, 68Ga-PRGD2 PET/CT showed different accumulation patterns for HGG of WHO grades III and IV. This is the first noninvasive integrin imaging study, to the best of our knowledge, conducted in preoperative patients with different grades of glioma, and it preliminarily indicated the effectiveness of this novel method for evaluating glioma grading and demarcation.
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影响因子：
4.8
作者：
Adachi, Y;Lakka, SS;Rao, JS
通讯作者：
Rao, JS
DOI：
10.2967/jnumed.111.088955
发表时间：
2012-05
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Doss M;Kolb HC;Zhang JJ;Bélanger MJ;Stubbs JB;Stabin MG;Hostetler ED;Alpaugh RK;von Mehren M;Walsh JC;Haka M;Mocharla VP;Yu JQ
通讯作者：
Yu JQ
影响因子：
4.7
作者：
Lang, Lixin;Li, Weihua;Guo, Ning;Ma, Ying;Zhu, Lei;Kiesewetter, Dale O.;Shen, Baozhong;Niu, Gang;Chen, Xiaoyuan
通讯作者：
Chen, Xiaoyuan
DOI：
10.1073/pnas.1120375109
发表时间：
2012-02-28
影响因子：
11.1
作者：
Holmes, Kristen M.;Annala, Matti;Zhang, Wei
通讯作者：
Zhang, Wei
影响因子：
4.9
作者：
Ji S;Czerwinski A;Zhou Y;Shao G;Valenzuela F;Sowiński P;Chauhan S;Pennington M;Liu S
通讯作者：
Liu S