Prevalence, clinical profile, and significance of left ventricular remodeling in the end-stage phase of hypertrophic cardiomyopathy
Prevalence, clinical profile, and significance of left ventricular remodeling in the end-stage phase of hypertrophic cardiomyopathy
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DOI：
10.1161/circulationaha.105.583500
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发表时间：
2006-07-18
期刊：
影响因子：
37.8
通讯作者：
Maron, Barry J.
中科院分区：
文献类型：
--
作者：
Harris, Kevin M.;Spirito, Paolo;Maron, Barry J.
背景-终末期（ES）是肥厚型心肌病（HCM）疾病谱中公认的一部分.频率，临床概况和过程，在这些patients和治疗策略仍然不完全defined.Methods和结果-三个HCM队列包括1259例患者，包括44（3.5%）的特征为ES与收缩功能障碍（射血分数< 50%，在休息;范围15%至49%）。ES的发病年龄范围很广（14至74岁），45%的患者
Background - End stage (ES) is a recognized part of the hypertrophic cardiomyopathy (HCM) disease spectrum. Frequency, clinical profile and course, and treatment strategies in these patients remain incompletely defined.Methods and Results - Three HCM cohorts comprised 1259 patients, including 44 (3.5%) characterized as ES with systolic dysfunction (ejection fraction < 50% at rest; range 15% to 49%). ES developed at a wide age range (14 to 74 years), with 45% of patients