Adenocarcinoma of the nose and paranasal sinuses: A retrospective study of diagnosis, histologic characteristics, and outcomes in 24 patients
Adenocarcinoma of the nose and paranasal sinuses: A retrospective study of diagnosis, histologic characteristics, and outcomes in 24 patients
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DOI：
10.1002/hed.20168
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发表时间：
2005-05-01
影响因子：
2.9
通讯作者：
Olsen, KD
中科院分区：
文献类型：
--
作者：
Orvidas, LJ;Lewis, JE;Olsen, KD
背景摘要鼻腔鼻窦腺癌是一种少见的肿瘤，其临床过程多变。确定了24例（17例男性）鼻窦腺癌。鼻阻塞是最常见的临床症状（75%），鼻子是最常见的受累部位（83%）。11例肿瘤（46%）为高级别（3级或4级）。23名患者（95%）接受了手术切除的尝试，7名患者出现肿瘤复发或残留病变。年龄和肿瘤分级与总生存率相关，肿瘤分级和颅内扩散与疾病死亡相关。结论。鼻腺癌的表现和治疗差异很大。鼻腺癌的一些低级别变体似乎与更有利的预后相关，并且根据肿瘤的范围，可以用较低侵袭性的治疗方法进行治疗。(c)2005 Wiley Periodicals，Inc.
Background. Adenocarcinomas of the sinonasal cavity are unusual tumors with variable clinical courses.Methods, We conducted a retrospective chart review between 1980 and 2001.Results. Twenty-four patients (17 men) with sinonasal adenocarcinoma were identified. Nasal obstruction was the most common presenting symptom (75%), and the nose was the most common site of involvement (83%). Eleven tumors (46%) were high grade (grade 3 or 4). Twenty-three patients (95%) underwent an attempt at surgical excision, with tumor recurrence or residual disease in seven. Age and tumor grade were associated with overall survival, and tumor grade and intracranial extension were associated with death from disease.Conclusions. Presentation and treatment for nasal adenocarcinoma vary widely. Some low-grade variants of nasal adenocarcinomas seem to be associated with a more favorable prognosis and, depending on the extent of the tumor, can be treated with less-aggressive therapy. (c) 2005 Wiley Periodicals, Inc.