Body mass index and mortality in patients with idiopathic pulmonary fibrosis
Body mass index and mortality in patients with idiopathic pulmonary fibrosis
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DOI：
10.1378/chest.06-2784
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发表时间：
2007-05-01
期刊：
影响因子：
9.6
通讯作者：
Ryu, Jay H.
中科院分区：
文献类型：
--
作者：
Alakhras, Mazen;Decker, Paul A.;Ryu, Jay H.
背景：研究特发性肺纤维化(IPF)患者的体重指数(BMI)与死亡率的关系。1994年至1996年在罗切斯特梅奥诊所就诊的IPF患者。这些患者符合目前公认的IPF定义。结果：在197例符合纳入标准的患者中，平均年龄(+/-SD)为71.4+/-8.9岁，137例患者(70%)为男性，平均BMI为28.2+/-4.6。根据体重指数将这些患者分为以下三组：25岁；25岁至30岁；以及30岁。体重指数<25的46例患者(23%)中位生存期为3.6年(1年生存率76%[95%可信区间(CI)65~90%]；3年生存率54%[95%可信区间(CI)41~70%])。第二组患者85例(43%)，BMI在25~30之间，中位生存期3.8年(1年生存率84%[95%可信区间76~92%]；3年生存率58%[95%可信区间48~70%])。最后一组包括66例(34%)BMI=30的患者，他们的中位生存期为5.8年(1年生存率91%[95%可信区间84~98%]；3年生存率69%[95%可信区间58~81%])。在比例风险回归模型中，生存与体重指数显著相关(体重指数每增加一次，危险比为0.93；95%可信区间为0.89~0.97；p=0.002)，体重指数越高，生存越好。
Background: To examine the relationship between body mass index (BMI) and mortality in patients with idiopathic pulmonary fibrosis (IPF).Methods: We studied a cohort of. patients with IPF who were seen at the Mayo Clinic Rochester from 1994 through 1996. These patients met the current consensus definition of IPF. We excluded patients who had received prior treatment for IPF, had no follow-up data, or had no pulmonary function results available at the index visit.Results: Of the 197 patients fulfilling the inclusion criteria, the mean ( +/- SD) age was 71.4 +/- 8.9 years, 137 patients (70%) were men, and the mean BMI was 28.2 +/- 4.6. These patients were categorized by BMI into the following three groups: < 25; 25 to 30; and >= 30. There were 46 patients (23%) with a BMI of < 25 who had a median survival time of 3.6 years (1-year survival rate, 76% [95% confidence interval (CI), 65 to 90%]; 3-year survival rate, 54% [95% CI, 41 to 70%]). The second group consisted of 85 patients (43%) with a BMI between 25 and 30 who had a median survival time of 3.8 years (1-year survival rate, 84% [95% CI, 76 to 92%]; 3-year survival rate, 58% [95% CI, 48 to 70%]). The final group consisted of 66 patients (34%) with a BMI of >= 30 and who had a median survival time of 5.8 years (1-year survival rate, 91% [95% CI, 84 to 98%]; 3-year survival rate, 69% [95% CI, 58 to 81%]). Using a proportional hazards regression model, survival was significantly associated with BMI (hazard ratio, 0.93 for each I-U increase in BMI; 95% CI, 0.89 to 0.97; p = 0.002) with increased BMI being associated with better survival.Conclusion: Higher BMI was associated with better survival in patients with IPF.