Attenuated adrenergic responses to exercise in women with fibromyalgia - A controlled study
Attenuated adrenergic responses to exercise in women with fibromyalgia - A controlled study
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DOI：
10.1016/j.ejpain.2007.07.007
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发表时间：
2008-04-01
影响因子：
3.6
通讯作者：
Roe, Cecilie
中科院分区：
文献类型：
--
作者：
Giske, Liv;Vollestad, Nina Kopke;Roe, Cecilie
广泛性疼痛和纤维肌痛（FM）的发病机制尚不清楚。下丘脑-垂体-肾上腺轴、交感神经系统和肌肉系统的反应改变被认为是重要的。本研究旨在确定：（i）FM患者对重复等长收缩的交感肾上腺反应是否改变，以及（ii）交感肾上腺反应是否与运动过程中的肌肉疲劳和疼痛相关。19名FM女性和19名年龄、吸烟和自我报告的身体活动相匹配的健康女性参加了本研究。最大随意收缩（MVC），重复等长收缩（6 s收缩和4 s休息阶段）进行与两个股四头肌在MVC的30%，直到耗尽。通过表面肌电图（EMG）记录股四头肌的肌肉活动。运动过程中，FM组血浆肾上腺素（Adr）、去甲肾上腺素（NAdr）和皮质醇（cortisol）的反应减弱（p < 0.001），而血浆NAdr和皮质醇的反应正常（p > 0.19）。在收缩阶段（p = 0.001），FM组的EMG振幅（%EMG（最大值））显著高于对照组。FM组对运动的感觉用力和疼痛反应高于对照组（p < 0.001），与交感肾上腺反应无关。在运动过程中，随着肌肉活动的增加，肌肉表现也发生了变化。女性FM表现出衰减肾上腺素反应重复等长运动。(C)2007年，国际疼痛研究协会欧洲分会联合会。由爱思唯尔有限公司出版。保留所有权利。
The pathogenesis of widespread pain and fibromyalgia (FM) is unknown. Altered responses from the hypothalamus-pituitary-adrenal axis, sympathetic nervous system and muscular system have been suggested as being of importance. The present study was undertaken to determine: (i) whether the sympathoadrenal response to repetitive isometric contractions until exhaustion is altered in patients with FM, and (ii) whether sympathoadrenal responses are associated with muscle fatigue and pain during exercise.Nineteen women with FM, and 19 healthy women matched for age, smoking and self-reported physical activity, participated. Maximal voluntary contraction (MVC), repetitive isometric contractions (6 s contraction and 4 s resting phases) were performed with both quadriceps muscles at 30% of MVC until exhaustion. Muscle activity was recorded from the quadriceps muscles by surface electromyography (EMG). Plasma adrenalin (Adr), noradrenalin (NAdr) and cortisol were measured and perceived exertion and pain reported during exercise.Attenuated Adr responses (p < 0.001) with normal plasma NAdr and cortisol (p > 0.19) responses were found during exercise in the FM group compared with the control group. Significantly higher EMG amplitude ( %EMG(max)) during the contraction phases (p = 0.001) was found in the FM than in the control group. Perceived exertion and pain responses to exercise were higher in the FM group than in the controls (p < 0.001), without relationship to the sympathoadrenal responses.In conclusion; the exercise was perceived as being more painful and strenuous in the FM group. Muscle performance was altered with increased muscle activity during the exercise. Women with FM showed an attenuated Adr response to repetitive isometric exercise. (C) 2007 European Federation of Chapters of the International Association for the Study of Pain. Published by Elsevier Ltd. All rights reserved.