Pro-survival signalling from the NMDA receptor.
Pro-survival signalling from the NMDA receptor.
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DOI：
10.1042/bst0340936
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发表时间：
2006-11
影响因子：
3.9
通讯作者：
Hardingham GE
中科院分区：
文献类型：
--
作者：
Hardingham GE
Ca2+ 通过离子型谷氨酸受体 NMDA 亚型流入，在哺乳动物中枢神经系统中发挥 Jekyll 和 Hyde 作用。虽然它介导中风和其他急性创伤引发的兴奋性毒性死亡，但越来越多的证据表明，NMDA 受体活性的生理水平可促进生存。了解这些相反作用背后的机制可能会导致选择性阻断促死亡信号传导的策略，这可能具有相当大的临床益处。
Ca2+ influx through the NMDA subtype of ionotropic glutamate receptors plays a Jekyll and Hyde role in the mammalian central nervous system. While it mediates excitotoxic death triggered by stroke and other acute trauma, there is growing evidence that physiological levels of NMDA receptor activity promote survival. Understanding the mechanisms that underlie these opposing effects may lead to strategies to selectively block pro-death signalling, which could have considerable clinical benefits.