THE RELATION BETWEEN THE DIVERGENCE OF SEQUENCE AND STRUCTURE IN PROTEINS
THE RELATION BETWEEN THE DIVERGENCE OF SEQUENCE AND STRUCTURE IN PROTEINS
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DOI：
10.1002/j.1460-2075.1986.tb04288.x
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发表时间：
1986-04-01
期刊：
影响因子：
11.4
通讯作者：
LESK, AM
中科院分区：
文献类型：
--
作者：
CHOTHIA, C;LESK, AM
同源蛋白具有保留相同的一般折叠的区域和折叠不同的区域。对于成对的远亲蛋白质（残基同一性. 20%），具有相同折叠的区域可以包含少于每个分子的一半。具有相同的一般折叠的区域在结构上的差异量随着氨基酸序列的分歧而增加。主链原子位置的均方根偏差Δ，与突变残基H的分数相关，表达式为：Δ（ANG）= 0.40 e1.87H。
Homologous proteins have regions which retain the same general fold and regions where the folds differ. For pairs of distantly related proteins (residue identity .apprx. 20%), the regions with the same fold may comprise less than half of each molecule. The regions with the same general fold differ in structure by amounts that increase as the amino acid sequences diverge. The root mean square deviation in the positions of the main chain atoms, .DELTA., is related to the fraction of mutated residues, H, by the expression: .DELTA.(.ANG.) = 0.40 e1.87H.