Comparison of the amblyopia treatment study HOTV and electronic-early treatment of diabetic retinopathy study visual acuity protocols in children aged 5 to 12 years
Comparison of the amblyopia treatment study HOTV and electronic-early treatment of diabetic retinopathy study visual acuity protocols in children aged 5 to 12 years
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DOI：
10.1016/j.ajo.2003.08.016
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发表时间：
2004-02-01
影响因子：
4.2
通讯作者：
Holmes, JM
中科院分区：
文献类型：
--
作者：
Rice, ML;Leske, DA;Holmes, JM
目得：比较两种已建立的视力方案：弱视治疗研究HOTV（ATS HOTV）视力方案和糖尿病视网膜病变电子早期治疗研究（E-ETDRS）方案。设计：前瞻性队列研究。方法：使用电子视力测试仪对236名5 ~ 12岁儿童进行拥挤HOTV和拥挤ETDRS验光（掌上电脑、个人电脑和显示器）。23%的儿童被归类为弱视，35%为未矫正的屈光不正，36%为正常，6%为其他。将视力测试结果转换为最小值的对数。结果：在发育正常儿童（n = 230）中，HOTV在5- 12岁儿童中的可测性为100%，E-ETDRS在7 - 12岁儿童中的可测性为100%。E-ETDRS测试可以在52%的5岁儿童和87%的6岁儿童中完成。与E-ETDRS相比，HOTV测量的视力性能更好（中位数差异0.06 logMAR [图表上的三个字母，五个字母/行]，P =.0001），并且在正常眼、屈光不正眼和弱视眼中发现了差异。在5- 12岁儿童中，ATS HOTV方案的视力表现略好于E-ETDRS，但平均低于logMAR水平。这种系统性差异是重要的，当医生改变测试模式，作为一个孩子的成熟，并应考虑解释最近和正在进行的弱视临床试验的结果。(C)2004年，Elsevier Inc. All rights reserved.
PURPOSE: To compare two established visual acuity protocols: the Amblyopia Treatment Study HOTV (ATS HOTV) visual acuity protocol and the ElectronicEarly Treatment of Diabetic Retinopathy Study (E-ETDRS) protocol, in children aged 5 to 12 years.DESIGN: Prospective cohort study.METHODS: Crowded HOTV optotypes and crowded ETDRS optotypes were presented to 236 consecutive children aged 5 to 12 years using an electronic visual acuity tester (Palm handheld, personal computer, and monitor). Twenty,three percent of the children were classified as amblyopic, 35% as having uncorrected refractive error, 36% as normal, and 6% as other. Visual acuity test results were converted to logarithm of mini. mal angle of resolution (logMAR) units for analysis.RESULTS: In developmentally normal children (n = 230), testability was 100% for HOTV in 5- to 12-year-olds and 100% for E-ETDRS in 7, to 12-year-olds. The E-ETDRS testing could be completed in 52% of 5-year-olds and in 87% of 6-year-olds. Visual acuity performance was better when measured by HOTV compared with E-ETDRS (median difference 0.06 logMAR [three letters on a chart with five letters/line], P =.0001), and the difference was found in normal eyes, eyes with refractive error, and amblyopic eyes.CONCLUSIONS: The ATS HOTV protocol yields slightly better visual acuity performance compared with E-ETDRS in 5- to 12-year-olds, but on average by less than a logMAR level. This systematic difference is important when a physician changes testing modality as a child matures and should be considered when interpreting the results of recent and ongoing clinical trials in amblyopia. (C) 2004 by Elsevier Inc. All rights reserved.