IgE antibodies to Pityrosporum orbiculare and Staphylococcus aureus in patients with very high serum total IgE
IgE antibodies to Pityrosporum orbiculare and Staphylococcus aureus in patients with very high serum total IgE
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血清总 IgE 极高的患者中的轮状糠秕孢子菌和金黄色葡萄球菌的 IgE 抗体
DOI：
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发表时间：
1992
影响因子：
6.1
通讯作者：
B. Petrini
中科院分区：
文献类型：
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作者：
S. Nordvall;L. Lindgren;S. Johansson;S. Johansson;B. Petrini
通过放射变应原吸附试验（RAST）对 81 名连续患者的血清 IgE 抗体进行检测，这些过敏原包括轮状糠秕孢子菌、白色念珠菌、红色毛癣菌、草枝孢子菌、金黄色葡萄球菌、动物皮屑、落叶树花粉、草花粉和食物，总 IgE ≥ 3000 kU/1。通过问卷收集有关特应性和传染病特征的数据。 P. orbicale 的 IgE 抗体浓度显着高于其他真菌，并且与动物皮屑和花粉的 IgE 抗体浓度相同。高水平的轮状疟原虫 IgE 抗体与当前的湿疹有关，尤其是当它是唯一的特应性表现且需要专科护理时。在逻辑回归分析中，轮状疟原虫的 IgE 抗体对当前湿疹具有最佳解释价值。头颈面部皮炎也与高水平的酵母特异性 IgE 有关。在少数患者中检测到金黄色葡萄球菌 IgE 抗体，且浓度较低。 6例患者有全身葡萄球菌感染史，临床表现与高免疫球蛋白血症E综合征非常相似。这六例中，有两例金黄色葡萄球菌 IgE 抗体水平最高。轮状酵母是人类正常皮肤微生物群的主要组成部分，其 IgE 抗体水平较高，这表明对这种酵母菌的过敏在湿疹中起着重要的致病作用。
Serum IgE antibodies were detected with the radioallergosorbent test (RAST) to a panel of allergens which included Pityrosporum orbiculare, Candida albicans, Trichophyton rubrum, Cladosporium herbarum, Staphylococcus aureus, animal dander, deciduous tree pollens, grass pollens and foods in 81 consecutive patients with total IgE ≥ 3000 kU/1. Data on atopic and infectious disease characteristics were collected by a questionnaire. IgE antibody concentrations to P. orbiculare were significantly higher than to the other fungi and of the same magnitude as those to animal danders and pollens. High levels of P. orbiculare IgE antibodies were associated with current eczema, especially when it was the only atopic manifestation and demanding specialist care. IgE antibodies to P. orbiculare had the best explanatory value for current eczema in logistic regression analysis. Head‐neck‐face dermatitis was also associated with high levels of specific IgE to the yeast. IgE antibodies to S. aureus were detected in few patients and at low concentrations. Six patients had a history of systemic staphylococcal infections and presented a clinical picture, which was very similar to the hyperimmunoglobulinaemia E syndrome. Among the six were the two cases with the highest levels of IgE antibodies to S. aureus. The demonstration of high levels of IgE antibodies to P. orbiculare, which is a major part of human normal skin microflora, suggests that allergy to this yeast plays an important pathogenic role in eczema.
高免疫球蛋白 E 综合征的临床和免疫学方面。
DOI：
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发表时间：
1988
期刊：
Hematology/oncology clinics of North America
影响因子：
--
作者：
Leung,DY;Geha,RS
通讯作者：
Geha,RS