INCREASED AORTIC STIFFNESS IN PATIENTS WITH TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS
INCREASED AORTIC STIFFNESS IN PATIENTS WITH TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS
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DOI：
10.1007/bf00274536
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发表时间：
1989-10-01
期刊：
影响因子：
8.2
通讯作者：
HEICKENDORFF, L
中科院分区：
文献类型：
--
作者：
OXLUND, H;RASMUSSEN, LM;HEICKENDORFF, L
使用材料测试机对来自 1 型（胰岛素依赖型）糖尿病患者以及年龄和性别匹配的对照受试者的主动脉样本的生物力学特性进行了分析。这些标本是从可见动脉粥样硬化区域之外的组织中制备的，以便区分主动脉的原发性 1 型糖尿病改变和由于动脉粥样硬化加剧导致的继发性改变。我们特别关注壁厚差异的生物力学参数校正和样本长度值的记录。在 1 型糖尿病患者的主动脉中，发现其伸展性显着降低，而其硬度则增加。延展性的降低与 1 型糖尿病的持续时间显着相关。机械性能的显着改变不能用在 1 型糖尿病患者中观察到的壁厚增加来解释，并且这些改变不能与胸主动脉动脉粥样硬化的等级相关。因此，本研究的结果强烈表明，1 型糖尿病患者的动脉结缔组织会发生变化，而与动脉粥样硬化的存在无关。血管壁的这种原发性改变可能在这些患者大血管疾病的发病机制中发挥作用。
The biomechanical properties of aortic samples from patients with Type 1 (insulin-dependent) diabetes mellitus and age- and sex-matched control subjects were analysed using a materials testing machine. The specimens were prepared from tissue outside areas of visible atherosclerosis in order to discriminate between primary Type 1 diabetic alterations in the aortae and secondary changes due to increased atherosclerosis. We paid special attention to the correction of biomechanical parameters for differences in wall thickness and registration of specimen length values. In the Type 1 diabetic aortae a marked reduction was found in the extensibility and an increase in their stiffness. The reduced extensibility was correlated significanlty to the duration of Type 1 diabetes. The pronounced alterations in the mechanical properties could not be explained by the increase in the wall thickness which was observed among the Type 1 diabetic patients and the alterations could not be correlated to the grade of atherosclerosis in the thoracic aorta. The results of the present study, therefore, strongly suggest that Type 1 diabetic patients develop alterations in the arterial connective tissue independent of the presence of atherosclerosis. Such primary alterations in the vessel wall may play a role in the pathogenesis of large vessel disease among these patients.