Blueberries Decrease Cardiovascular Risk Factors in Obese Men and Women with Metabolic Syndrome
Blueberries Decrease Cardiovascular Risk Factors in Obese Men and Women with Metabolic Syndrome
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DOI：
10.3945/jn.110.124701
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发表时间：
2010-09-01
影响因子：
4.2
通讯作者：
Lyons, Timothy J.
中科院分区：
文献类型：
--
作者：
Basu, Arpita;Du, Mei;Lyons, Timothy J.
在所有水果中，浆果由于其高多酚含量而显示出实质性的心脏保护益处。然而，它们在改善肥胖代谢综合征特征和相关心血管危险因素方面的功效研究有限。我们研究了蓝莓补充剂对肥胖男性和女性代谢综合征、脂质过氧化和炎症的影响。48例代谢综合征患者[男性4例，女性44例；BMI: 37.8 +/- 2.3 kg/m(2)；年龄：50.0 +/- 3.0 y（平均+/- SE）]在一项随机对照试验中，连续8周每天饮用冻干蓝莓饮料（50克冻干蓝莓，类似于350克新鲜蓝莓）或等量液体（对照组，960毫升水）。在筛查和研究的第4周和第8周进行了人体测量和血压测量，饮食摄入量评估和空腹抽血。蓝莓补充组的收缩压和舒张压下降幅度（分别为- 6%和-4%）大于对照组（- 1.5%和-1.2%）（P < 0.05），而血清葡萄糖浓度和血脂没有受到影响。蓝莓组血浆氧化LDL和血清丙二醛、羟烯醛浓度下降幅度分别为- 28%和-17%，显著高于对照组（-9%和-9%）（P < 0.01）。我们的研究表明，蓝莓可以改善代谢综合征的某些特征和相关的心血管风险因素，在膳食可达到的剂量下。中国生物医学工程学报，2014,31(2):444 - 444。
Among all fruits, berries have shown substantial cardio-protective benefits due to their high polyphenol content. However, investigation of their efficacy in improving features of metabolic syndrome and related cardiovascular risk factors in obesity is limited. We examined the effects of blueberry supplementation on features of metabolic syndrome, lipid peroxidation, and inflammation in obese men and women. Forty-eight participants with metabolic syndrome [4 males and 44 females; BMI: 37.8 +/- 2.3 kg/m(2); age: 50.0 +/- 3.0 y (mean +/- SE)] consumed freeze-dried blueberry beverage (50 g freeze-dried blueberries, similar to 350 g fresh blueberries) or equivalent amounts of fluids (controls, 960 mL water) daily for 8 wk in a randomized controlled trial. Anthropometric and blood pressure measurements, assessment of dietary intakes, and fasting blood draws were conducted at screening and at wk 4 and 8 of the study. The decreases in systolic and diastolic blood pressures were greater in the blueberry-supplemented group (-6 and -4%, respectively) than in controls (-1.5 and -1.2%) (P < 0.05), whereas the serum glucose concentration and lipid profiles were not affected. The decreases in plasma oxidized LDL and serum malondialdehyde and hydroxynonenal concentrations were greater in the blueberry group (-28 and -17%, respectively) than in the control group (-9 and -9%) (P < 0.01). Our study shows blueberries may improve selected features of metabolic syndrome and related cardiovascular risk factors at dietary achievable doses. J. Nutr. 140: 1582-1587, 2010.