Atriopeptin-immunoreactive neurons in the brain: presence in cardiovascular regulatory areas.
Atriopeptin-immunoreactive neurons in the brain: presence in cardiovascular regulatory areas.
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大脑中的心房肽免疫反应性神经元：存在于心血管调节区域。
DOI：
10.1126/science.2858127
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Needleman,P
中科院分区：
文献类型：
--
作者：
Saper,CB;Standaert,DG;Currie,MG;Schwartz,D;Geller,DM;Needleman,P
制备心房opeptin III和心房opepti原前体分子溴化氰片段的抗血清，用于检测心房opeptin样免疫反应物质在大鼠心脏和大脑中的分布。右心房和左心房肌细胞中可见这种物质的颗粒，核周区域密度最大。心房收缩素样免疫反应物质在心脏中的分布与先前报道的心房分泌颗粒一致。在含有该物质的大脑神经元中，在下丘脑和脑桥被盖中观察到。脑内心房肽可能在神经系统中作为一种神经递质控制血容量和血成分，与血源性心房肽调节的生理功能相同。
Antisera to atriopeptin III and to a cyanogen bromide fragment of the precursor molecule atriopeptigen were prepared and used to examine the distribution of atriopeptin-like immunoreactive material in the heart and brain of the rat. Granules of this material were seen in myocytes throughout the right and left atria and were densest in the perinuclear region. The distribution of atriopeptin-like immunoreactive material in the heart is consistent with previous reports of atrial secretory granules. In the brain neurons containing the material were observed in the hypothalamus and the pontine tegmentum. Atriopeptin in the brain may serve as a neurotransmitter in neural systems controlling blood volume and composition, the same physiological functions regulated by blood-borne atriopeptin.