Developmental trajectories of body mass index from childhood into late adolescence and subsequent late adolescence-young adulthood cardiometabolic risk markers
Developmental trajectories of body mass index from childhood into late adolescence and subsequent late adolescence-young adulthood cardiometabolic risk markers
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DOI：
10.1186/s12933-019-0813-5
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发表时间：
2019-01-19
影响因子：
9.3
通讯作者：
Noethlings, Ute
中科院分区：
文献类型：
--
作者：
Oluwagbemigun, Kolade;Buyken, Anette E.;Noethlings, Ute
背景：关于儿童期到青春期晚期的身体质量指数（BMI）轨迹、其决定因素和随后的心脏代谢风险标志物的报道很少，特别是在欧洲人群中。此外，考虑到BMI的性别差异，以及BMI与某些心脏代谢危险标志物之间的性别特异性关联，有必要进行性别特异性研究。方法使用来自多特蒙德营养与人体测量纵向设计研究的样本，我们通过潜在（类别）生长模型探索了354名男性和335名女性在4至18岁期间BMI标准偏差评分（SDS）的性别特异性轨迹。通过逻辑回归评估轨迹的决定因素。我们通过随机森林回归确定了与BMI SDS轨迹高度相关的心脏代谢风险标记，最后我们使用广义线性模型来研究已确定的心脏代谢风险标记在成对轨迹之间的差异。结果我们在男性和女性中分别观察到四种轨迹：低正常体重轨迹、中等正常体重轨迹、高正常体重轨迹和超重轨迹，以及三种轨迹：低正常体重轨迹、中等正常体重轨迹和高正常体重轨迹。无论男女，孕妇孕前体重指数越高，其超重轨迹越高，正常体重轨迹越高。此外，有工作的母亲和头胎身份与女性的高正常体重轨迹有关。BMI SDS轨迹与男性高密度脂蛋白-胆固醇和白细胞介素-18 （IL-18）以及女性舒张压和白细胞介素-6 （IL-6）相关。然而，只有超重男性的IL-18水平明显高于体重正常的男性。结论：我们确定了从儿童期到青春期晚期BMI SDS的性别特异性明显轨迹，较高的母亲孕前BMI是高正常体重和超重轨迹的共同决定因素，超重轨迹与青春期晚期至成年早期IL-18升高有关。本研究强调孕妇孕前BMI在超重中的作用，并强调IL-18是一生中超重的心脏代谢标志。
BackgroundReports on body mass index (BMI) trajectories from childhood into late adolescence, their determinants, and subsequent cardiometabolic risk markers, particularly among European populations have been few. Moreover, sex-specific investigation is necessary considering the sex difference in BMI, and the sex-specific association between BMI and some cardiometabolic risk markers.MethodsUsing a sample from the DOrtmund Nutritional and Anthropometric Longitudinally Designed study, we explored sex-specific trajectories of the BMI standard deviation score (SDS) from 4 to 18years of age in 354 males and 335 females by latent (class) growth models. The determinants of trajectory were assessed by logistic regression. We identified cardiometabolic risk markers that were highly associated with BMI SDS trajectory by random forest regression, and finally we used generalized linear models to investigate differences in the identified cardiometabolic risk markers between pairs of trajectories.ResultsWe observed four: low-normal weight', mid-normal weight', high-normal weight', and overweight', and three: low-normal weight', mid-normal weight', and high-normal weight' trajectories in males and females, respectively. Higher maternal prepregnancy BMI was associated with the overweight' trajectory, and with high-normal weight' trajectory in both sexes. In addition, employed mothers and first-born status were associated with high-normal weight' trajectory in females. BMI SDS trajectory was associated with high-density lipoprotein-cholesterol and interleukin-18 (IL-18) in males, and diastolic blood pressure and interleukin-6 (IL-6) in females. However, only males following the overweight' trajectory had significantly higher IL-18 when compared to their low-normal weight' counterpart.ConclusionsWe identified sex-specific distinct trajectories of BMI SDS from childhood into late adolescence, higher maternal prepregnancy BMI as a common determinant of the high-normal weight' and overweight' trajectories, and overweight' trajectory being associated with elevated IL-18 in late adolescence-young adulthood. This study emphasizes the role of maternal prepregnancy BMI in overweight, and highlights IL-18 as a cardiometabolic signature of overweight across life.