Go-no-go task performance improvement after anodal transcranial DC stimulation of the left dorsolateral prefrontal cortex in major depression
Go-no-go task performance improvement after anodal transcranial DC stimulation of the left dorsolateral prefrontal cortex in major depression
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DOI：
10.1016/j.jad.2006.10.026
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发表时间：
2007-08-01
影响因子：
6.6
通讯作者：
Fregni, Felipe
中科院分区：
文献类型：
--
作者：
Boggio, Paulo S.;Bermpohl, Felix;Fregni, Felipe
背景资料：我们最近发现，重复经颅磁刺激（rTMS）的背外侧前额叶皮层（DLPFC）可以影响的性能在一个情感去不去（AGN）的任务。我们的目的是扩展以前的调查测试是否一个会话的阳极经颅直流电刺激（tDCS）的左DLPFC，与阳极枕和假tDCS相比，影响这个AGN任务的性能。方法：26名抑郁症患者随机接受左侧DLPFC的阳极tDCS，枕叶皮质或假tDCS（对于三种条件，将阴极电极放置在额极区域上）。在治疗前后立即进行AGN任务。性能的变化（治疗前和治疗后）进行了比较，各组的治疗和相关的汉密尔顿抑郁量表（HDRS）评分changes.Results：结果表明，阳极刺激的左DLPFC是唯一的条件，引起了显着改善任务表现所示的正确反应的数量增加。此外，这种效果是特定的数字与积极的情感内容。这种性能增强与tDCS治疗10天后的情绪变化无关。局限性：虽然tDCS的影响不如rTMS集中，但它可以诱导更长时间和更强的皮质兴奋性调制，结论：我们的研究结果表明，左侧DLPFC活动与积极的情绪处理有关，证实并扩展了先前的研究结果，即右侧前额叶皮层和眶额皮层活动与情绪处理有关。此外，tDCS对情绪和认知的影响似乎是独立的抑郁症。这些证据共同揭示了与重度抑郁症的情绪处理有关的神经回路。(c)2006 Elsevier B.V.保留所有权利。
Background: We recently showed that repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) can affect the performance in an affective go-no-go (AGN) task. We aimed to extend this previous investigation testing whether one session of anodal transcranial direct current stimulation (tDCS) of the left DLPFC, as compared with anodal occipital and sham tDCS, affects this AGN task performance.Methods: Twenty-six patients with major depression were randomized to receive anodal tDCS of the left DLPFC, occipital cortex or sham tDCS (the cathode electrode was placed over the frontopolar area for the three conditions). An AGN task was performed immediately before and after treatment. Performance changes (pre and post-treatment) were compared across groups of treatment and correlated with Hamilton Depression Rating Scale (HDRS) score changes.Results: The results show that anodal stimulation of the left DLPFC was the only condition that induced a significant improvement in task performance as shown by the increase in the number of correct responses. In addition, this effect was specific for figures with positive emotional content. This performance enhancement was not correlated with mood changes after 10 days of tDCS treatment.Limitations: Although the effects of tDCS are less focal than rTMS, it can induce a longer and stronger modulation of cortical excitability,Conclusions: Our findings suggest that left DLPFC activity is associated with positive emotional processing, confirming and extending results of previous studies that associated right DLPFC and orbito-frontal cortex activity with emotional processing. Furthermore the effects of tDCS on mood and cognition seem to be independent in major depression. These lines of evidence together shed light on the neural circuitry involved with emotional processing in major depression. (c) 2006 Elsevier B.V. All rights reserved.