Mitogen-Activated Protein Kinase Cascade in Breast Cancer
Mitogen-Activated Protein Kinase Cascade in Breast Cancer
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DOI：
10.1159/000055273
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发表时间：
1999-10
期刊：
影响因子：
3.5
通讯作者：
M. Maemura;Y. Iino;Y. Koibuchi;T. Yokoe;Y. Morishita
中科院分区：
文献类型：
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作者：
M. Maemura;Y. Iino;Y. Koibuchi;T. Yokoe;Y. Morishita
丝裂原激活蛋白（MAP）激酶被认为在多种细胞事件（包括癌发生和肿瘤进展）中发挥核心作用。事实上，MAP 激酶、酪氨酸磷酸化 MAP 激酶和 Raf-1 蛋白在癌性人体组织中的表达量高于周围非癌性腺体。在7,12-二甲基苯并[a]蒽诱导的大鼠乳腺癌模型中，雌激素促进肿瘤生长，卵巢切除术和抗雌激素他莫昔芬（TAM）抑制肿瘤生长。卵巢切除术抑制 MAP 激酶、酪氨酸磷酸化 MAP 激酶和 Raf-1 的表达，而雌激素和 TAM 在去势条件下诱导 MAP 激酶和 Raf-1 的表达。据报道，MAP 激酶在乳腺癌细胞的进展过程中被激活，因此 TAM 对 MAP 激酶级联的雌激素作用可能是恶性进展的原因。
The mitogen-activated protein (MAP) kinase is considered to play a central role in diverse cellular events including carcinogenesis and tumor progression. Indeed, expression of MAP kinase, tyrosine-phosphorylated MAP kinase, and Raf-1 protein was greater in cancerous human tissues than in the surrounding noncancerous glands. In a 7,12-dimethylbenz[a]anthracene-induced rat mammary carcinoma model, estrogen promoted and ovariectomy and antiestrogen, tamoxifen (TAM) inhibited the tumor growth. Ovariectomy suppressed expression of MAP kinase, tyrosine-phosphorylated MAP kinase and Raf-1, whereas estrogen as well as TAM induced expression of MAP kinase and Raf-1 under castrated conditions. Since it was reported that MAP kinase was activated during the progression of breast carcinoma cells, such estrogenic actions of TAM toward the MAP kinase cascade might be responsible for malignant progression.