Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model
Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model
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DOI：
10.1001/jama.294.23.3003
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发表时间：
2005-12-21
影响因子：
120.7
通讯作者：
Rajagopalan, S
中科院分区：
文献类型：
--
作者：
Sun, QH;Wang, AX;Rajagopalan, S
最近的研究表明，城市地区吸入颗粒物暴露与心血管事件的易感性之间存在联系;然而，确切的机制仍有待确定。目的在易感疾病模型中，验证亚慢性暴露于环境相关颗粒物（即使在低浓度下）可增强动脉粥样硬化并改变血管紧张度的假设。设计、设置和参与者于7月21日，2004年和2005年1月12日，28载脂蛋白E-/-基于随机分配，用正常食物或高脂肪食物喂养（apoE（-/-））小鼠，并将其暴露于小于2.5 μ m的浓缩环境颗粒（PM2.5）或过滤空气（FA）在纽约州的燕尾服，每天6小时，每周5天，共6个月。主要指标胸主动脉和腹主动脉复合粥样硬化斑块和血管张力结果高脂组PM2.5和FA的平均复合斑块面积分别为41.5%（9.8%）和26.2%（8.6%）（P
Context Recent studies have suggested a link between inhaled particulate matter exposure in urban areas and susceptibility to cardiovascular events; however, the precise mechanisms remain to be determined.Objective To test the hypothesis that subchronic exposure to environmentally relevant particulate matter, even at low concentrations, potentiates atherosclerosis and alters vasomotor tone in a susceptible disease model.Design, Setting, and Participants Between July 21, 2004, and January 12, 2005, 28 apolipoprotein E-/- (apoE(-/-)) mice were, based on randomized assignments, fed with normal chow or high-fat chow and exposed to concentrated ambient particles of less than 2.5 mu m (PM2.5) or filtered air (FA) in Tuxedo, NY, for 6 hours per day, 5 days per week for a total of 6 months.Main Outcome Measures Composite atherosclerotic plaque in the thoracic and abdominal aorta and vasomotor tone changes.Results In the high-fat chow group, the mean (SD) composite plaque area of PM2.5 vs FA was 41.5% (9.8%) vs 26.2% (8.6%), respectively (P