Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs.
Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs.
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DOI：
10.1155/2012/391546
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发表时间：
2012
影响因子：
--
通讯作者：
Fernández N
中科院分区：
文献类型：
--
作者：
Martínez-Salas E;Piñeiro D;Fernández N
细胞蛋白质组的组成受到多个过程的控制，其中最重要的过程之一是翻译起始。大多数真核细胞 mRNA 通过帽子依赖性或扫描翻译启动模式启动翻译，这种机制依赖于 m7G(5')ppp(5')N（称为帽子）的识别。然而，编码细胞在应激旁路条件下生存所需蛋白质的 mRNA 会抑制帽子依赖性翻译；这些 mRNA 通常在其 5'UTR 中包含内部核糖体进入位点 (IRES) 元件，介导内部翻译起始。感染真核细胞的病毒基因组表达的 mRNA 也利用了这种机制。在本文中，我们讨论了理解启动跨真核生物翻译的替代方法的最新进展。
The composition of the cellular proteome is under the control of multiple processes, one of the most important being translation initiation. The majority of eukaryotic cellular mRNAs initiates translation by the cap-dependent or scanning mode of translation initiation, a mechanism that depends on the recognition of the m7G(5′)ppp(5′)N, known as the cap. However, mRNAs encoding proteins required for cell survival under stress bypass conditions inhibitory to cap-dependent translation; these mRNAs often harbor internal ribosome entry site (IRES) elements in their 5′UTRs that mediate internal initiation of translation. This mechanism is also exploited by mRNAs expressed from the genome of viruses infecting eukaryotic cells. In this paper we discuss recent advances in understanding alternative ways to initiate translation across eukaryotic organisms.