Androgen control of immunocompetence in the male house finch, Carpodacus mexicanus Muller
Androgen control of immunocompetence in the male house finch, Carpodacus mexicanus Muller
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DOI：
10.1242/jeb.01531
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发表时间：
2005-04-01
影响因子：
2.8
通讯作者：
Cortez, L
中科院分区：
文献类型：
--
作者：
Deviche, P;Cortez, L
免疫功能障碍（ICH）假说预测，性腺雄激素睾酮（T）水平的升高需要强制性的成本，如免疫抑制，但支持这种免疫抑制影响的证据是模棱两可的。为了研究这个问题，成年雄性家雀，Carpodacus mexicanus，暴露于短的日子和长期治疗的T-填充（T男性; N = 10）或空（C男性; N = 10）硅橡胶胶囊。替西莫司管理增加血浆T水平和泄殖腔突起的大小，雄激素依赖性第二性征。为了研究体液免疫，雀类接受了绵羊红细胞（SRBC）的注射，我们用血凝试验测量了这些细胞的抗体循环浓度。所有雄性动物在每周注射4次SRBC后均产生抗体。第四次注射后5天，T和C雄性的抗体滴度没有差异，但2周后T雄性比C雄性低59%。为了研究细胞介导的免疫，我们测量了注射植物血凝素（PHA）的局部炎症反应。PHA注射后1天，T和C雄性动物的这种反应相似，但注射后2天，T雄性动物的反应比C雄性动物低58%。因此，T和C男性安装类似的体液和细胞介导的免疫反应，但T治疗损害这些反应的维持。结果表明T升高的免疫抑制作用与ICH假设一致。
The immunocompetence handicap (ICH) hypothesis predicts that elevated levels of the gonadal androgen testosterone (T) entail obligatory costs, such as immunosuppression, but evidence supporting this immunosuppressive influence is equivocal. To investigate this question, adult males house finches, Carpodacus mexicanus, were exposed to short days and chronically treated with T-filled (T males; N = 10) or empty (C males; N = 10) Silastic capsules. Testosterone administration increased plasma T levels and the size of the cloacal protuberance, an androgen-dependent secondary sexual characteristic. To study humoral immunity, finches received injections of sheep red blood cells (SRBC) and we measured circulating concentrations of antibodies to these cells with a hemagglutination test. All males produced antibodies following four SRBC injections at weekly intervals. Antibody titers in T and C males did not differ 5 days after the fourth injection, but were 59% lower in T than C males 2 weeks later. To study cell-mediated immunity, we measured the local inflammatory response to an injection of phytohemaglutinin (PHA). This response in T and C males was similar 1 day after PHA injection, but was 58% less in T than C males 2 days following the injection. Thus, T and C males mounted similar humoral and cell-mediated immune responses, but T treatment compromised maintenance of these responses. The results, demonstrating immunosuppressive effects of elevated T, are consistent with the ICH hypothesis.