Phytoestrogen intake and endometrial cancer risk
Phytoestrogen intake and endometrial cancer risk
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DOI：
10.1093/jnci/djg015
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发表时间：
2003-08-06
期刊：
影响因子：
--
通讯作者：
Lee, MM
中科院分区：
文献类型：
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作者：
Horn-Ross, PL;John, EM;Lee, MM
背景：子宫内膜癌的发生在很大程度上与长期接触非对立雌激素有关。植物雌激素(即在植物食品中发现的弱雌激素)可能具有抗雌激素作用。我们评估了饮食摄入代表三类植物雌激素(异黄酮类、香豆素和木脂素)的七种特定化合物与子宫内膜癌风险之间的关系。方法：在一项来自大旧金山湾区的病例对照研究中，我们收集了500名年龄在35-79岁之间的非裔美国人、拉丁裔和白人妇女的饮食信息，她们在1996至1999年间被诊断为子宫内膜癌，并收集了通过随机数字拨号确定的470名年龄和种族匹配的对照妇女的饮食信息。非条件Logistic回归分析用于估计优势比(OR)和95%可信区间(CI)。结果：异黄酮类(OR=0.59，95%CI=0.37~0.93)和木脂素消耗(OR=0.68，95%CI=0.44~1.1)与子宫内膜癌风险呈负相关。这些相关性在绝经后妇女中略强(异黄酮类和木脂素类的OR=0.44，95%CI=0.26~0.77和OR=0.57，95%CI=0.34~0.97)。肥胖绝经后摄入较少植物雌激素的妇女患子宫内膜癌的风险最高(OR=6.9，95%CI=3.3~14.5，与非肥胖绝经后摄入相对较高的异黄酮者相比)；然而，肥胖与植物雌激素摄入之间的交互作用并不具有统计学意义。结论：一些植物雌激素类化合物，在典型的美式饮食中消耗的水平，与降低子宫内膜癌的风险有关。
Background: The development of endometrial cancer is largely related to prolonged exposure to unopposed estrogens. Phytoestrogens (i.e., weak estrogens found in plant foods) may have antiestrogenic effects. We evaluated the associations between dietary intake of seven specific compounds representing three classes of phytoestrogens (isoflavones, coumestans, and lignans) and the risk of endometrial cancer. Methods: In a case-control study from the greater San Francisco Bay Area, we collected dietary information from 500 African American, Latina, and white women aged 35-79 years who were diagnosed with endometrial cancer between 1996 and 1999 and from 470 age- and ethnicity-matched control women identified through random-digit dialing. Unconditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Isoflavone (OR = 0.59, 95% CI = 0.37 to 0.93 for the highest versus lowest quartile of exposure) and lignan (OR = 0.68, 95% CI = 0.44 to 1.1) consumptions were inversely related to the risk of endometrial cancer. These associations were slightly stronger in postmenopausal women (OR = 0.44, 95% CI = 0.26 to 0.77 and OR = 0.57,95% CI = 0.34 to 0.97 for isoflavones and lignans, respectively). Obese postmenopausal women consuming relatively low amounts of phytoestrogens had the highest risk of endometrial cancer (OR = 6.9, 95% CI = 3.3 to 14.5 compared with non-obese postmenopausal women consuming relatively high amounts of isoflavones); however, the interaction between obesity and phytoestrogen intake was not statistically significant. Conclusion: Some phytoestrogenic compounds, at the levels consumed in the typical American-style diet, are associated with reduced risk of endometrial cancer.