Mean platelet volume is increased in patients with severe obstructive sleep apnea
Mean platelet volume is increased in patients with severe obstructive sleep apnea
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DOI：
10.3109/00365513.2010.520733
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发表时间：
2010-11-01
影响因子：
2.1
通讯作者：
Akkaya, Ahmet
中科院分区：
文献类型：
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作者：
Varol, Ercan;Ozturk, Onder;Akkaya, Ahmet
阻塞性睡眠呼吸暂停（OSA）患者血小板活化和聚集增加与心血管并发症密切相关。本研究的目的是评估平均血小板体积（MPV），这是OSA患者血小板活化的指标。95名被转诊接受OSA评估的受试者接受了夜间多导睡眠图检查。采集血液样品用于MPV测定。根据呼吸暂停低通气指数（AHI）将受试者分为三组：第1组：无OSA的对照组（AHI < 5，n = 24）;第2组：轻中度OSA患者（AHI：5-30，n = 42）;重度OSA患者的体重指数（BMI）显著高于对照组（31.5 +/- 4.0 vs. 28.2 +/- 5.0; p = 0.02）。重度OSA患者的MPV显著高于对照组（8.9 +/- 1.0 vs. 8.2 +/- 0.7 fl; p = 0.01）。对71例阻塞性睡眠呼吸暂停（OSA）患者进行相关性分析，结果表明，平均通气量（MPV）与睡眠呼吸暂停指数（AHI）（p < 0.001，r = 0.44）和呼吸窘迫指数（DI）（p = 0.001，r = 0.37）相关。在多变量回归分析中，当MPV与其他研究变量（如年龄、性别和BMI）独立时，MPV与AHI（β = 0.44，p < 0.001）和DI（β = 0.38，p < 0.001）独立相关。我们发现重度OSA患者的MPV显著高于对照组，且MPV与AHI和DI相关。
Increased platelet activation and aggregation which are closely related to cardiovascular complications have been reported in patients with obstructive sleep apnea (OSA). The aim of this study was to assess the mean platelet volume (MPV), an indicator of platelet activation in patients with OSA. The 95 subjects referred for evaluation of OSA underwent overnight polysomnography. Blood samples were taken for MPV determination. According to the apnea-hypopnea index (AHI), subjects were divided into three groups; group 1: control subjects without OSA (AHI < 5, n = 24), group 2: patients with mild to moderate OSA (AHI: 5-30, n = 42), and group 3: severe OSA (AHI > 30, n = 29). Body mass index (BMI) of patients with severe OSA was significantly higher than control subjects (31.5 +/- 4.0 vs. 28.2 +/- 5.0; p = 0.02). The MPV was significantly higher in patients with severe OSA than in the control group (8.9 +/- 1.0 vs. 8.2 +/- 0.7 fl; p = 0.01). Correlation analysis within 71 patients with OSA indicated that MPV was correlated with AHI (p < 0.001, r = 0.44) and DI (p = 0.001, r = 0.37). In multivariate regression analysis, when MPV was taken as independent with other study variables which are potential confounders such as age, gender and BMI, MPV was independently correlated with both AHI (beta = 0.44, p < 0.001) and DI (beta = 0.38, p < 0.001). We have shown that MPV was significantly higher in patients with severe OSA when compared with control subjects and MPV was correlated with AHI and DI.