Effect of atrial natriuretic peptide on muscle sympathetic activity and its reflex control in human heart failure
Effect of atrial natriuretic peptide on muscle sympathetic activity and its reflex control in human heart failure
复制标题
DOI：
10.1161/01.cir.99.14.1810
复制
发表时间：
1999-04-13
期刊：
影响因子：
37.8
通讯作者：
Floras, JS
中科院分区：
文献类型：
--
作者：
Abramson, BL;Ando, S;Floras, JS
背景-本研究的目的是确定心钠素（ANP）是否对心力衰竭患者静息时和非扩张性下体负压（LBNP）时的肌肉交感神经活动（MSNA）产生相对抑制作用，方法和结果：15名男性（年龄39+/-2岁[平均值+/-SE]）扩张型心肌病（射血分数18+/-3%）患者接受静脉注射ANP（50 μ g推注，然后50 ng . kg（-1）。min（-1））和硝酸甘油（NTG，8 mg/min）作为血流动力学对照。在每次输注MSNA期间，在-6和-12 mmHg LBNP之前和期间记录血压（BP）、中心静脉压（CVP）和心率（HR）。NTG和ANP引起CVP和舒张压的相似和显著降低，但静息MSNA没有增加。LBNP在-6 mm Hg时降低CVP（P
Background-The purpose of this study was to determine if atrial natriuretic peptide (ANP) exerts a relative inhibitory effect on muscle sympathetic nerve activity (MSNA) at rest and during nonhypotensive lower body negative pressure (LBNP) in heart failure, as in healthy subjects.Methods and Results-Fifteen men (age 39+/-2 years [mean+/-SE]) with dilated cardiomyopathy (ejection fraction 18+/-3%) received intravenous ANP (50 mu g bolus, then 50 ng . kg(-1) . min(-1)) and nitroglycerin (NTG, 8 mg/min) as a hemodynamic control. During each infusion MSNA, blood pressure (BP), central venous pressure (CVP), and heart rate (HR) were recorded before and during LBNP at -6 and -12 mm Hg. NTG and ANP caused similar and significant reductions in CVP and diastolic BP, but resting MSNA did not increase with either infusion. LBNP at -6 mm Hg lowered CVP (P