Structural, magnetic and toxicity studies of ferrite particles employed as contrast agents for magnetic resonance imaging thermometry
Structural, magnetic and toxicity studies of ferrite particles employed as contrast agents for magnetic resonance imaging thermometry
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DOI：
10.1016/j.jmmm.2019.165981
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发表时间：
2020-03-01
影响因子：
2.7
通讯作者：
Celinski, Zbigniew
中科院分区：
文献类型：
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作者：
Alghamdi, Noweir;Stroud, John;Celinski, Zbigniew
我们进行了全面的结构，磁性和毒性的研究Mg 1-xZnxFe 2 O 4和Cu 1-xZnxFe 2 O 4铁氧体，我们计划使用磁共振成像测温的造影剂。通过标准陶瓷技术制备样品。它们的结构特性进行了研究与X-射线衍射系统，并使用Rietveld方法，使我们能够确定阳离子分布的数据进行了分析。用超导量子干涉仪、振动样品磁强计和穆斯堡尔谱仪研究了MgZn和CuZn铁氧体的磁性。磁力测量与XRD结果交叉相关，并与穆斯堡尔谱测定的磁性进行比较，使我们能够了解所研究铁氧体的磁性结构。温度依赖的磁性测量被用作指导，以选择最合适的MgZn和CuZn铁氧体组合物用于在人体温度附近的MRI测温。炎症研究表明，从毒理学角度来看，MgZn铁氧体更适合用于MRI测温。
We carried out comprehensive structural, magnetic and toxicity studies of Mg1-xZnxFe2O4 and Cu1-xZnxFe2O4 ferrites that we plan to use as contrast agents for magnetic resonance-imaging thermometry. Samples were prepared by a standard ceramic technique. Their structural properties were investigated with an x-ray diffraction system, and data was analyzed using the Rietveld method that allowed us to determine cations distribution. Magnetic properties of MgZn and CuZn ferrites were studied using a superconducting quantum interference device magnetometer, a vibrating sample magnetometer, and Mossbauer spectrometer. Magnetometry measurements were cross-correlated with XRD results and compared with magnetic properties determined by Mossbauer spectroscopy, allowing us to understand the magnetic structure of studied ferrites. The temperature dependent magnetic measurements were used as guidance to select the most suitable MgZn and CuZn ferrites compositions for MRI thermometry near human body temperature. The inflammation studies indicated that MgZn ferrites are more suitable from the toxicology point of view for MRI thermometry.