Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs
Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs
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DOI：
10.1081/ncn-100002341
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发表时间：
2001-01-01
影响因子：
1.3
通讯作者：
Mulato, AS
中科院分区：
文献类型：
--
作者：
Cihlar, T;Ho, ES;Mulato, AS
hOAT 1是一种能够有效转运无环核苷膦酸酯（ANP）的肾膜蛋白。当在CHO细胞中表达时，hOAT 1介导ANP的摄取和细胞毒性，表明其在与西多福韦CMV治疗和高剂量阿德福韦HIV治疗相关的肾毒性中起积极作用。尽管替诺福韦可被hOAT 1有效转运，但在分离的人近端肾小管细胞中未显示出任何显著的细胞毒性，这与在长期替诺福韦治疗的HIV感染患者中观察到的肾毒性缺乏相关。
hOAT1 is a renal membrane protein able to efficiently transport acyclic nucleoside phosphonates (ANPs). When expressed in CHO cells, hOAT1 mediates the uptake and cytotoxicity of ANPs suggesting that it plays an active role in the nephrotoxicity associated with cidofovir CMV therapy and high-dose adefovir HIV therapy. Although efficiently transported by hOAT1, tenofovir did not show any significant cytotoxicity in isolated human proximal tubular cells, which correlates with the lack of nephrotoxicity observed in HIV-infected patients on prolonged tenofovir therapy.