Regulation of Inflammatory Response to Polyglycolic Acid Scaffolds through Incorporation of Sodium Tripolyphosphate
Regulation of Inflammatory Response to Polyglycolic Acid Scaffolds through Incorporation of Sodium Tripolyphosphate
复制标题
通过掺入三聚磷酸钠调节聚乙醇酸支架的炎症反应
DOI：
10.1016/j.eurpolymj.2019.109349
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发表时间：
2019
影响因子：
6
通讯作者：
Ying Yang
中科院分区：
文献类型：
--
作者：
Jiapeng Zhang;Chaobo Song;Yuqing Han;Zhenhao Xi;Ling Zhao;Lian Cen;Ying Yang
Polyglycolic acid (PGA) is a typical polyester with successful clinical and commercial applications. It causes severe host response and needs modification according to clinical cases. The expression of the pro-healing cytokine, IL-10, from macrophages as indicators of immune-response to PGA medical devices can be the key to be revealed. We thereby intended to modify PGA to affect its degradation profile and modulate the secretion of cytokines by macrophages. Sodium tripolyphosphate (TPP) was incorporated into PGA scaffolds as fillers via a scCO2foaming process. A porcine subcutaneous model was further employed to evaluate the inflammation and the expression profiles of macrophages (IL-10 and IL-1β as well as their phenotypes) in these implants. It was shown that IL-1β and IL-6 were both inhibitedin vitroin PGA and PGA-TPP groups without dependence on pH. The secretion of TNF-α was stimulated when pH was 6.1 and was inhibited by acidosis with pH of 3.6. IL-10 was also suppressed when pH was 3.6.In vivoexpression of IL-1β was increased in both groups. However, IL-10 exhibited higher values in PGA-TPP group than in PGA one, although a decreasing trend appeared in PGA-TPP implants from the 2nd to the 4th week. The infiltration of leukocytes was still severe in PGA scaffolds after two weeks post-surgery, while this was evidently relieved in PGA-TPP ones. In summary, the incorporation of TPP into PGA implants could be an efficient way to relief the inflammatory response and to improve the clinical outcomes of translational polyester implants.
