Increased Vancomycin Susceptibility in Mycobacteria: a New Approach To Identify Synergistic Activity against Multidrug-Resistant Mycobacteria
Increased Vancomycin Susceptibility in Mycobacteria: a New Approach To Identify Synergistic Activity against Multidrug-Resistant Mycobacteria
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DOI：
10.1128/aac.04856-14
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发表时间：
2015-06
影响因子：
4.9
通讯作者：
K. Soetaert;Céline Rens;Xiao-ming Wang;J. De Bruyn;M. Lanéelle;F. Laval;A. Lemassu;M. Daffé;P. Bifani;V. Fontaine;P. Lefèvre
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文献类型：
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作者：
K. Soetaert;Céline Rens;Xiao-ming Wang;J. De Bruyn;M. Lanéelle;F. Laval;A. Lemassu;M. Daffé;P. Bifani;V. Fontaine;P. Lefèvre
ABSTRACT Mycobacterium tuberculosis is wrapped in complex waxes, impermeable to most antibiotics. Comparing Mycobacterium bovis BCG and M. tuberculosis mutants that lack phthiocerol dimycocerosates (PDIM) and/or phenolic glycolipids with wild-type strains, we observed that glycopeptides strongly inhibited PDIM-deprived mycobacteria. Vancomycin together with a drug targeting lipid synthesis inhibited multidrug-resistant (MDR) and extensively drug-resistant (XDR) clinical isolates. Our study puts glycopeptides in the pipeline of potential antituberculosis (TB) agents and might provide a new antimycobacterial drug-screening strategy.
