Structural basis of efficient contagion: measles variations on a theme by parainfluenza viruses.
Structural basis of efficient contagion: measles variations on a theme by parainfluenza viruses.
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DOI：
10.1016/j.coviro.2014.01.004
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发表时间：
2014-04
影响因子：
5.9
通讯作者：
Cattaneo, Roberto
中科院分区：
文献类型：
--
作者：
Mateo, Mathieu;Navaratnarajah, Chanakha K.;Cattaneo, Roberto
四个附着蛋白和三个融合蛋白亚基演奏副流感病毒的细胞进入音乐会。虽然这些病毒中的许多结合唾液酸进入细胞，但野生型麻疹仅结合两种组织特异性蛋白，淋巴受体信号传导淋巴细胞活化分子（SLAM）和上皮受体nectin-4。SLAM在血凝素的茎头连接附近结合。Nectin-4结合位于血凝素β-螺旋桨头的叶片4和5之间的疏水槽。突变的疫苗株血凝素结合除了普遍存在的蛋白质CD 46，这解释了衰减。麻疹病毒入场音乐会有四个乐章。行板：病毒接管免疫系统。活泼的快板：它在上呼吸道上皮细胞中迅速扩散。“瞄准”赋格：多才多艺的管弦乐队起飞。突如其来：病毒以迅雷不及掩耳之势离开宿主。注意：音乐是有感染力的。
A quartet of attachment proteins and a trio of fusion protein subunits play the cell entry concert of parainfluenza viruses. While many of these viruses bind sialic acid to enter cells, wild type measles binds exclusively two tissue-specific proteins, the lymphatic receptor signaling lymphocytic activation molecule (SLAM), and the epithelial receptor nectin-4. SLAM binds near the stalk-head junction of the hemagglutinin. Nectin-4 binds a hydrophobic groove located between blades 4 and 5 of the hemagglutinin β-propeller head. The mutated vaccine strain hemagglutinin binds in addition the ubiquitous protein CD46, which explains attenuation. The measles virus entry concert has four movements. Andante misterioso: the virus takes over the immune system. Allegro con brio: it rapidly spreads in the upper airway’s epithelia. “Targeting” fugue: the versatile orchestra takes off. Presto furioso: the virus exits the host with thunder. Be careful: music is contagious.
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