ROSTRAL MEDULLARY CHOLINERGIC MECHANISMS AND CHRONIC STRESS-INDUCED HYPERTENSION
ROSTRAL MEDULLARY CHOLINERGIC MECHANISMS AND CHRONIC STRESS-INDUCED HYPERTENSION
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DOI：
10.1016/0165-1838(90)90187-n
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发表时间：
1990-12-01
期刊：
影响因子：
--
通讯作者：
LI, P
中科院分区：
文献类型：
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作者：
LIN, Q;LI, P
本工作旨在研究延髓头端腹外侧区（rVLM）的胆碱能机制与慢性应激诱发的高血压发病率之间的关系。 在麻醉条件下，将东莨菪碱（1.18 nmol/位点）双侧显微注射到 rVLM 中，慢性应激诱发的高血压大鼠比正常血压大鼠产生更大的抑制反应。 当东莨菪碱注射到 rVLM 中时，在正常血压和高血压大鼠中观察到类似的心动过缓效应。 采用放射免疫法测定正常血压和高血压大鼠延髓头端乙酰胆碱（Ach）含量和胆碱乙酰转移酶（ChAT）活性。 高血压大鼠Ach含量和ChAT活性显着升高，且升高主要发生在延髓头侧部。 这些结果表明，rVLM中的胆碱能机制可能在慢性应激过程中被激活，这种激活可能参与了慢性应激诱发的高血压的发病机制。
This work was designed to study the relationship between the cholinergic mechanisms in the rostral ventrolateral medulla (rVLM) and the incidence of hypertension induced by chronic stress. Under anaesthetized conditions, bilateral microinjection of scopolamine (1.18 nmol/site) into the rVLM produced a much greater depressor response in chronic stress-induced hypertensive rats than in normotensive rats. Similar bradycardic effects were observed in both the normotensive and the hypertensive rats when scopolamine was injected into the rVLM. Acetylcholine (Ach) content and choline acetyltransferase (ChAT) activity in rostral medulla were determined by radioimmunoassay both in the normotensive and the hypertensive rats. Ach content and ChAT activity increased significantly in the hypertensive rats, and such increase mainly occurred within the ventral part of the rostral medulla. These results suggest that the cholinergic mechanisms in the rVLM may be activated during chronic stress and such activation may be involved in the pathogenesis of the hypertension induced by chronic stress.