Indiana Palliative Excellence in Alzheimer's Care Efforts (IN-PEACE): Protocol for a randomized controlled trial in persons with advanced dementia.
Indiana Palliative Excellence in Alzheimer's Care Efforts (IN-PEACE): Protocol for a randomized controlled trial in persons with advanced dementia.
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印第安纳州阿尔茨海默病姑息治疗卓越计划 (IN-PEACE)：针对晚期痴呆症患者的随机对照试验方案。
DOI：
10.1016/j.cct.2023.107217
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发表时间：
2023
影响因子：
2.2
通讯作者：
Sachs,GregA
中科院分区：
文献类型：
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作者：
Holtz,LauraR;Kroenke,Kurt;Gao,Sujuan;Hickman,SusanE;Torke,AlexiaM;Johnson,NinaM;Pemberton,Amy;Vrobel,Andrea;Pan,Minmin;Sachs,GregA
背景痴呆症影响着美国650万人，预计到2060年这个数字将翻一番。超过一半的痴呆症患者在家中死亡，给患者和护理人员造成了巨大的负担。然而，有一个基于社区的姑息治疗干预先进dementives.ObjectivesThe印第安纳州姑息卓越阿尔茨海默氏症的护理工作（在和平）的研究是一项随机试验，以测试的有效性的协作主要远程保健家庭为基础的干预与居住在社区和他们的主要，非正式的照顾者的晚期痴呆症的人。主要目的是确定这种姑息治疗集中的支持性干预在减少痴呆的神经精神症状方面是否上级常规治疗。其次，干预对其他患者症状的影响（例如，疼痛）、照顾者痛苦和抑郁以及急诊科（艾德）/住院事件进行检查。MethodsThe研究人群由参与者对组成，所述参与者对包括痴呆症患者和他们的主要非正式照顾者。痴呆症患者必须年满65岁，临床诊断为中度至重度痴呆症。共有201对人口统计学和社会经济学不同的参与者被随机分配到IN-PEACE护理协调干预（n= 99）或常规护理（n= 102）。结果评估在基线进行，每季度进行一次，持续2年（3、6、9、12、15、18、21和24个月）。DiscussionIN-PEACE结果将为社区中大量晚期痴呆患者的护理提供信息，并使非正式护理人员能够提供有效的家庭护理。试验注册：clinicaltrials.gov标识符：NCT 03773757。
BackgroundDementia affects 6.5 million persons in the U.S., a number which is expected to double by 2060. More than half of persons with dementia die at home, creating an enormous burden for both patients and caregivers. However, there is a paucity of research on community-based palliative care interventions for advanced dementia.ObjectivesThe Indiana Palliative Excellence in Alzheimer's Care Efforts (IN-PEACE) study is a randomized trial to test the effectiveness of a collaborative predominantly telehealth home-based intervention for persons with advanced dementia residing in the community and their primary, informal caregivers. The primary aim is to determine if this palliative care focused supportive intervention is superior to usual care in reducing neuropsychiatric symptoms of dementia. Secondarily, intervention effects on other patient symptoms (e.g., pain), caregiver distress and depression, and emergency department (ED)/hospitalization events are examined.MethodsThe study population consists of participant pairs comprising a person with dementia and their primary, informal caregiver. The person with dementia must be ≥65 years old, with a clinical diagnosis of moderate to severe dementia. A total of 201 demographically and socioeconomically diverse participant pairs have been randomized to the IN-PEACE care coordination intervention (n= 99) or usual care (n= 102). Outcome assessments are conducted at baseline, and quarterly for up to 2 years (3, 6, 9, 12, 15, 18, 21, and 24 months).DiscussionIN-PEACE results will inform care for the large number of individuals with advanced dementia residing in the community and enable informal caregivers to provide effective home-based care.Trial registration: clinicaltrials.gov Identifier: NCT03773757.