Apical GLUT2 - A major pathway of intestinal sugar absorption
Apical GLUT2 - A major pathway of intestinal sugar absorption
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DOI：
10.2337/diabetes.54.10.3056
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发表时间：
2005-10-01
期刊：
影响因子：
7.7
通讯作者：
Brot-Laroche, E
中科院分区：
文献类型：
--
作者：
Kellett, GL;Brot-Laroche, E
了解决定餐后血糖浓度波动的机制是糖尿病管理中有效控制血糖的核心。肠道糖吸收就是其中一种机制，对其在实验性糖尿病中增加的研究使我们提出了一种新的糖吸收模型。在根尖GLUT2模型中，由Na(+)/葡萄糖共转运体SGLT1运输的葡萄糖在几分钟内促进GLUT2插入根尖膜，因此该机制在含有高血糖指数碳水化合物的膳食的同化过程中起作用，提供了比SGLT1多三倍的吸收促进成分。在这里，我们回顾了顶端GLUT2模型的证据，并描述了顶端GLUT2是如何通过膳食糖、局部和内分泌激素、细胞能量状态、应激和糖尿病等多种短期营养传感机制的目标。这些机制表明，根尖GLUT2是一个潜在的治疗靶点，可以通过新的饮食或药物方法来控制肠道糖的输送，从而改善血糖控制。
Understanding the mechanisms that determine postprandial fluctuations in blood glucose concentration is central for effective glycemic control in the management of diabetes. Intestinal sugar absorption is one such mechanism, and studies on its increase in experimental diabetes led us to propose a new model of sugar absorption. In the apical GLUT2 model, the glucose transported by the Na(+)/glucose cotransporter SGLT1 promotes insertion of GLUT2 into the apical membrane within minutes, so that the mechanism operates during assimilation of a meal containing high-glycemic index carbohydrate to provide a facilitated component of absorption up to three times greater than by SGLT1. Here we review the evidence for the apical GLUT2 model and describe how apical GLUT2 is a target for multiple short-term nutrient-sensing mechanisms by dietary sugars, local and endocrine hormones, cellular energy status, stress, and diabetes. These mechanisms suggest that apical GLUT2 is a potential therapeutic target for novel dietary or pharmacological approaches to control intestinal sugar delivery and thereby improve glycemic control.